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Nanosystems: Physics, Chemistry, Mathematics, 2021, Volume 12, Issue 1, Pages 81–112
DOI: https://doi.org/10.17586/2220-8054-2021-12-1-81-112 (Mi nano590) 		 
This article is cited in 9 scientific papers (total in 9 papers)

CHEMISTRY AND MATERIAL SCIENCE

Physicochemical and biochemical properties of the Keplerate-type nanocluster polyoxomolybdates as promising components for biomedical use

A. A. Ostroushkoa, K. V. Grzhegorzhevskiia, S. Yu. Medvedevaba, I. F. Getteb, M. O. Tonkushinaa, I. D. Gagarina, I. G. Danilovaab

a Ural Federal University named after the first President of Russia B. N. Yeltsin, Ekaterinburg, Russia
b Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences, Ekaterinburg, Russia
Full-text PDF (1522 kB) Citations (9)
DOI: https://doi.org/10.17586/2220-8054-2021-12-1-81-112
Abstract: The paper discusses the results of a research on physicochemical and biochemical properties of the Keplerate-type molybdenum-based nanocluster polyoxometalates (POMs), which show promise in the field of biomedicine as a means of targeted drug delivery, including the transport to immune privileged organs. POMs can be considered as components of releasing systems, including the long-acting ones with feedback (for controlling the drug active component release rate). POMs are promising drugs for the treatment of anemia. Also, the paper deals with the results of studies of POM effect on living systems at the molecular and cellular levels, at that of individual organs, and on the organism as a whole. The mechanism and kinetics of POM destruction and possibilities of stabilization, the oscillatory phenomena manifestation, the formation of POM conjugates with bioactive substances which can be released during the destruction of POM, with polymer components, and with indicator fluorescent dyes, as well as forecasts for further research, are considered.
Keywords: Keplerate-type nanocluster polyoxomolybdates, physicochemical and biochemical properties, impact on living systems, means of targeted delivery, releasing systems, prolonged action.
Funding agency Grant number
Ministry of Science and Higher Education of the Russian Federation AAAA-A20-120061990010-7 (FEUZ-2020-0052)
AAAA-A18-118020590107-0
Ministry of Education and Science of the Russian Federation 02.A03.21.0006
Russian Science Foundation 19-73-00177
The paper was prepared in the framework of implementation of the State Assignment from the Ministry of Education and Science of the Russian Federation (Projects Nos. AAAA-A20-120061990010-7 (FEUZ-2020-0052) and AAAA-A18-118020590107-0), as well as of the Program for Increasing Competitiveness of UrFU (financially supported according to the Decree No. 211 of the Government of the Russian Federation, Contract No. 02.A03.21.0006). The research aimed at creating the long-time drug release systems with feedback was carried out within the framework of the project of the Russian Science Foundation No. 19-73-00177.
Received: 27.03.2020
Bibliographic databases:
Document Type: Article
Language: English
Citation: A. A. Ostroushko, K. V. Grzhegorzhevskii, S. Yu. Medvedeva, I. F. Gette, M. O. Tonkushina, I. D. Gagarin, I. G. Danilova, “Physicochemical and biochemical properties of the Keplerate-type nanocluster polyoxomolybdates as promising components for biomedical use”, Nanosystems: Physics, Chemistry, Mathematics, 12:1 (2021), 81–112
Citation in format AMSBIB
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\by A.~A.~Ostroushko, K.~V.~Grzhegorzhevskii, S.~Yu.~Medvedeva, I.~F.~Gette, M.~O.~Tonkushina, I.~D.~Gagarin, I.~G.~Danilova
\paper Physicochemical and biochemical properties of the Keplerate-type nanocluster polyoxomolybdates as promising components for biomedical use
\jour Nanosystems: Physics, Chemistry, Mathematics
\yr 2021
\vol 12
\issue 1
\pages 81--112
\mathnet{http://mi.mathnet.ru/nano590}
\crossref{https://doi.org/10.17586/2220-8054-2021-12-1-81-112}
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\elib{https://elibrary.ru/item.asp?id=46822138}
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    • This publication is cited in the following 9 articles:
    Citing articles in Google Scholar: Russian citations, English citations
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