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Nanosystems: Physics, Chemistry, Mathematics, 2020, Volume 11, Issue 3, Pages 324–332
DOI: https://doi.org/10.17586/2220-8054-2020-11-3-324-332
(Mi nano531)
 

This article is cited in 6 scientific papers (total in 6 papers)

CHEMISTRY AND MATERIAL SCIENCE

CeO$_{2}$ nanoparticles as free radical regulators in biological systems

M. M. Sozarukovaa, E. V. Proskurninab, A. Y. Baranchikova, V. K. Ivanova

a Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Leninsky Prospect, 31, Moscow, 119991, Russia
b Research Centre for Medical Genetics, Moskvorechie St, 1, Moscow, 115522, Russia
Abstract: Cerium dioxide nanoparticles possess unique physical and chemical properties, among which the enzyme-like activity is of particular interest. In particular, they are able to perform the functions of pro- and antioxidant enzymes, such as superoxide dismutase (SOD), catalase, and peroxidase. Due to the advantages associated with pH and temperature stability and low cost, CeO$_{2}$ nanoparticles can be considered as promising mimetics of these enzymes. In this paper, the antioxidant activity of a citrate-stabilized colloidal suspension of CeO$_{2}$ nanoparticles has been studied using chemiluminometry in model systems generating superoxide anion radical and hydrogen peroxide. In the lucigenin/xanthine/xanthine oxidase system, generating a superoxide anion radical, CeO$_{2}$ nanoparticles exhibit antioxidant properties increasing upon conjugation with SOD. When interacting with hydrogen peroxide, CeO$_{2}$ nanoparticles exhibit peroxidase-like activity. In the combined ROS generating system, lucigenin/Co(II)/H$_{2}$O$_{2}$, CeO$_{2}$ nanoparticles demonstrated prooxidant activity.
Keywords: cerium dioxide nanoparticles, superoxide anion radical, hydrogen peroxide, nanozymes, superoxide dismutase, peroxidase, chemiluminescence.
Funding agency Grant number
Russian Science Foundation 19-13-00416
This work was supported by the Russian Science Foundation (project No. 19-13-00416).
Received: 19.02.2020
Bibliographic databases:
Document Type: Article
Language: English
Citation: M. M. Sozarukova, E. V. Proskurnina, A. Y. Baranchikov, V. K. Ivanov, “CeO$_{2}$ nanoparticles as free radical regulators in biological systems”, Nanosystems: Physics, Chemistry, Mathematics, 11:3 (2020), 324–332
Citation in format AMSBIB
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\paper CeO$_{2}$ nanoparticles as free radical regulators in biological systems
\jour Nanosystems: Physics, Chemistry, Mathematics
\yr 2020
\vol 11
\issue 3
\pages 324--332
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\crossref{https://doi.org/10.17586/2220-8054-2020-11-3-324-332}
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\elib{https://elibrary.ru/item.asp?id=45864107}
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  • This publication is cited in the following 6 articles:
    Citing articles in Google Scholar: Russian citations, English citations
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    Nanosystems: Physics, Chemistry, Mathematics
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