Abstract:
Nanocrystalline cerium dioxide is known as a unique redox active nanomaterial. Cerium dioxide is considered as the basis for future biomedical preparations, including radioprotectors. In the framework of this study, we synthesized citrate-stabilized CeO2 nanoparticles and carried out a comprehensive in vitro assessment of their radioprotective properties on a NCTC L929 murine fibroblast culture. It was shown that CeO2 nanoparticles ensure the survival of murine fibroblasts, even after high-dose X-ray irradiation, reducing the number of dead cells in the culture and modulating the mRNA level of the key antioxidant enzymes — superoxide dismutase 1 (SOD1) and superoxide dismutase 2 (SOD2). The results obtained confirm the potential for studying the properties of CeO2 nanoparticles as basic materials for designing new efficient and safe preparations for protection against ionizing radiation.
This research has been supported by the Russian Science Foundation (project 19-13-00416).
Received: 22.06.2019 Revised: 04.10.2019
Bibliographic databases:
Document Type:
Article
PACS:
68.65.k, 81.20.n, 82.70.Dd, 87.80.-y
Language: English
Citation:
N. R. Popova, T. O. Shekunova, A. L. Popov, I. I. Selezneva, V. K. Ivanov, “Cerium oxide nanoparticles provide radioprotective effects upon X-ray irradiation by modulation of gene expression”, Nanosystems: Physics, Chemistry, Mathematics, 10:5 (2019), 564–572
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\by N.~R.~Popova, T.~O.~Shekunova, A.~L.~Popov, I.~I.~Selezneva, V.~K.~Ivanov
\paper Cerium oxide nanoparticles provide radioprotective effects upon X-ray irradiation by modulation of gene expression
\jour Nanosystems: Physics, Chemistry, Mathematics
\yr 2019
\vol 10
\issue 5
\pages 564--572
\mathnet{http://mi.mathnet.ru/nano470}
\crossref{https://doi.org/10.17586/2220-8054-2019-10-5-564-572}
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https://www.mathnet.ru/eng/nano/v10/i5/p564
This publication is cited in the following 3 articles:
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S. S. Sorokina, E. E. Karmanova, V. A. Anikina, N. R. Popova, “Radiation Dermatitis: Development of the Problem”, Biol Bull Russ Acad Sci, 51:11 (2024), 3556
Faezeh Mozafari, Hamid Rashidzadeh, Murat Barsbay, Mohammadreza Ghaffarlou, Marziyeh Salehiabar, Ali Ramazani, Morteza Abazari, Mohammad-Amin Rahmati, Gopal Niraula, Surender K. Sharma, Hossein Danafar, Nanomedicine and Nanotoxicology, Harnessing Materials for X-ray Based Cancer Therapy and Imaging, 2022, 175
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