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Nanosystems: Physics, Chemistry, Mathematics, 2019, Volume 10, Issue 1, Pages 92–101
DOI: https://doi.org/10.17586/2220-8054-2019-10-1-92-101 (Mi nano420) 		 
This article is cited in 2 scientific papers (total in 2 papers)

CHEMISTRY AND MATERIAL SCIENCE

PVP-stabilized tungsten oxide nanoparticles inhibit proliferation of NCTC L929 mouse fibroblasts via induction of intracellular oxidative stress

A. L. Popova, A. M. Ermakova, T. O. Shekunovabc, A. B. Shcherbakovd, O. N. Ermakovaa, O. S. Ivanovac, N. R. Popovaa, A. Ye. Baranchikovc, V. K. Ivanovc

a Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow region, 142290, Russia
b Lomonosov Moscow State University, Moscow, 119991, Russia
c Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Moscow, 119991, Russia
d Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, Kyiv, D0368, Ukraine
Full-text PDF (6973 kB) Citations (2)
DOI: https://doi.org/10.17586/2220-8054-2019-10-1-92-101
Abstract: In this study, photochromic PVP-stabilized tungsten oxide nanoparticles (WO$_{3-x}$ NPs) were shown to exhibit a dose-dependent cytotoxic effect on mouse fibroblasts in vitro. WO$_{3-x}$ NPs reduce viability and proliferative activity of the cells via induction of intracellular oxidative stress leading to apoptosis and cell death. WO$_{3-x}$ NPs modulate the mRNA expression of a wide range of genes responsible for oxidative stress and the cell redox-system.
Keywords: tungsten oxide nanoparticles, cytotoxicity, apoptosis, fibroblasts.
Funding agency Grant number
Russian Science Foundation 18-73-10150
This study was funded by Russian Science Foundation (project 18-73-10150).
Received: 03.01.2019
Revised: 22.01.2019
Bibliographic databases:
Document Type: Article
PACS: 68.65.k, 81.20.n, 82.70.Dd, 82.50.Hp, 87.17.Ee
Language: English
Citation: A. L. Popov, A. M. Ermakov, T. O. Shekunova, A. B. Shcherbakov, O. N. Ermakova, O. S. Ivanova, N. R. Popova, A. Ye. Baranchikov, V. K. Ivanov, “PVP-stabilized tungsten oxide nanoparticles inhibit proliferation of NCTC L929 mouse fibroblasts via induction of intracellular oxidative stress”, Nanosystems: Physics, Chemistry, Mathematics, 10:1 (2019), 92–101
Citation in format AMSBIB
\Bibitem{PopErmShe19}
\by A.~L.~Popov, A.~M.~Ermakov, T.~O.~Shekunova, A.~B.~Shcherbakov, O.~N.~Ermakova, O.~S.~Ivanova, N.~R.~Popova, A.~Ye.~Baranchikov, V.~K.~Ivanov
\paper PVP-stabilized tungsten oxide nanoparticles inhibit proliferation of NCTC L929 mouse fibroblasts \emph{via} induction of intracellular oxidative stress
\jour Nanosystems: Physics, Chemistry, Mathematics
\yr 2019
\vol 10
\issue 1
\pages 92--101
\mathnet{http://mi.mathnet.ru/nano420}
\crossref{https://doi.org/10.17586/2220-8054-2019-10-1-92-101}
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\elib{https://elibrary.ru/item.asp?id=37035522}
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