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Nanosystems: Physics, Chemistry, Mathematics, 2018, Volume 9, Issue 4, Pages 537–543
DOI: https://doi.org/10.17586/2220-8054-2018-9-4-537-543 (Mi nano341) 		 
CHEMISTRY AND MATERIAL SCIENCE

Cerium oxide nanoparticles increase the cytotoxicity of TNF-alpha in vitro

O. Shydlovskaa, E. Kharchenkob, N. Zholobaka, A. Shcherbakova, A. Maryninb, O. Ivanovac, A. Baranchikovc, V. Ivanovcd

a Zabolotny Institute of Microbiology and Virology NANU, Kyiv, Ukraine
b National University of Food Technologies, Kyiv, Ukraine
c Kurnakov Institute of General and Inorganic Chemistry, Moscow, Russia
d National Research Tomsk State University, Tomsk, Russia
Full-text PDF (466 kB)
DOI: https://doi.org/10.17586/2220-8054-2018-9-4-537-543
Abstract: Cerium oxide nanoparticles (CeONP) were used as the modifying agent for the recombinant tumor necrosis factor-$\alpha$ and recombinant tumor necrosis factor-$\alpha$-thymosin-$\alpha$1 (rhTNF and rhTNF-T). A notable increase of the biological activity of proteins with antitumor effect was demonstrated. It was established that the cytotoxicity of rTNF-T+CeONP composite increases with the duration of exposure to 7 days. Modification of rTNF-T with cerium oxide nanoparticles provides a stronger and more stable cytotoxic effect in Hep-2, L929, and A-549 tumor cell lines.
Keywords: cerium oxide nanoparticles, tumor necrosis factor, nano-biocomposite, biological activity, antitumor effect.
Received: 02.05.2018
Revised: 18.06.2018
Bibliographic databases:
Document Type: Article
PACS: 81.07.Bc, 81.16.Be, 87.14.ef
Language: English
Citation: O. Shydlovska, E. Kharchenko, N. Zholobak, A. Shcherbakov, A. Marynin, O. Ivanova, A. Baranchikov, V. Ivanov, “Cerium oxide nanoparticles increase the cytotoxicity of TNF-alpha in vitro”, Nanosystems: Physics, Chemistry, Mathematics, 9:4 (2018), 537–543
Citation in format AMSBIB
\Bibitem{ShyKhaZho18}
\by O.~Shydlovska, E.~Kharchenko, N.~Zholobak, A.~Shcherbakov, A.~Marynin, O.~Ivanova, A.~Baranchikov, V.~Ivanov
\paper Cerium oxide nanoparticles increase the cytotoxicity of TNF-alpha in vitro
\jour Nanosystems: Physics, Chemistry, Mathematics
\yr 2018
\vol 9
\issue 4
\pages 537--543
\mathnet{http://mi.mathnet.ru/nano341}
\crossref{https://doi.org/10.17586/2220-8054-2018-9-4-537-543}
\isi{https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=Publons&SrcAuth=Publons_CEL&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=000454046200014}
\elib{https://elibrary.ru/item.asp?id=35450438}
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