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CHEMISTRY AND MATERIAL SCIENCE
Cerium oxide nanoparticles increase the cytotoxicity of TNF-alpha in vitro
O. Shydlovskaa, E. Kharchenkob, N. Zholobaka, A. Shcherbakova, A. Maryninb, O. Ivanovac, A. Baranchikovc, V. Ivanovcd a Zabolotny Institute of Microbiology and Virology NANU, Kyiv, Ukraine
b National University of Food Technologies, Kyiv, Ukraine
c Kurnakov Institute of General and Inorganic Chemistry, Moscow, Russia
d National Research Tomsk State University, Tomsk, Russia
Abstract:
Cerium oxide nanoparticles (CeONP) were used as the modifying agent for the recombinant tumor necrosis factor-$\alpha$ and recombinant tumor necrosis factor-$\alpha$-thymosin-$\alpha$1 (rhTNF and rhTNF-T). A notable increase of the biological activity of proteins with antitumor effect was demonstrated. It was established that the cytotoxicity of rTNF-T+CeONP composite increases with the duration of exposure to 7 days. Modification of rTNF-T with cerium oxide nanoparticles provides a stronger and more stable cytotoxic effect in Hep-2, L929, and A-549 tumor cell lines.
Keywords:
cerium oxide nanoparticles, tumor necrosis factor, nano-biocomposite, biological activity, antitumor effect.
Received: 02.05.2018 Revised: 18.06.2018
Citation:
O. Shydlovska, E. Kharchenko, N. Zholobak, A. Shcherbakov, A. Marynin, O. Ivanova, A. Baranchikov, V. Ivanov, “Cerium oxide nanoparticles increase the cytotoxicity of TNF-alpha in vitro”, Nanosystems: Physics, Chemistry, Mathematics, 9:4 (2018), 537–543
Linking options:
https://www.mathnet.ru/eng/nano341 https://www.mathnet.ru/eng/nano/v9/i4/p537
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Abstract page: | 125 | Full-text PDF : | 12 |
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