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Nanosystems: Physics, Chemistry, Mathematics, 2018, Volume 9, Issue 1, Pages 120–122
DOI: https://doi.org/10.17586/2220-8054-2018-9-1-120-122 (Mi nano142) 		 
FROM GUEST EDITORIAL

New superparamagnetic fluorescent Fe@C-C$_5$ON$_2$H$_{10}$-Alexa Fluor 647 nanoparticles for biological applications

A. S. Garaninaab, I. I. Kireevc, I. B. Alievac, A. G. Majougabd, V. A. Davydove, S. Murugesanf, V. N. Khabasheskuf, V. N. Agafonova, R. E. Uzbekovfg

a GREMAN, UMR CNRS 7347, Francois Rabelais University, Tours, France
b National University of Science and Technology "MISiS", Moscow, Russia
c Belozersky Institute of PhysicoChemical Biology, Moscow State University, Moscow, Russia
d Faculty of Chemistry, Lomonosov Moscow State University, Moscow, Russia
e L. F. Vereshchagin Institute for High Pressure Physics of the RAS, Moscow, Russia
f Center for Technology Innovation, Baker Hughes a GE Company, Houston, TX, USA
g Faculty of Bioengineering and Bioinformatics, Moscow State University, Moscow, Russia
Full-text PDF (235 kB)
DOI: https://doi.org/10.17586/2220-8054-2018-9-1-120-122
Abstract: The structure and physical properties of superparamagnetic Fe@C nanoparticles (Fe@C NPs) as well as their uptake by living cells and behavior inside the cell were investigated. Magnetic capacity of Fe@C NPs was compared with Fe$_7$C$_3$@C NPs investigated in our previous work, and showed higher value of magnetic saturation, 75 emu.g$^{-1}$ (75 Am$^2\cdot$ kg$^{-1}$), against 54 emu.g$^{-1}$ (54 Am$^2\cdot$ kg$^{-1}$) for Fe$_7$C$_3$@C. The surface of Fe@C NPs was alkylcarboxylated and further aminated for covalent linking to the molecules of fluorochrome Alexa Fluor 647. Fluorescent Fe@C-C$_5$ON$_2$H$_{10}$-Alexa Fluor 647 NPs (Fe@C-Alexa NPs) were incubated with HT1080 human fibrosarcoma cells and investigated using fluorescent, confocal laser scanning and transmission electron microscopy. No toxic effect on the cell physiology was observed. In a magnetic field, the NPs became aligned along the magnetic lines inside the cells.
Keywords: superparamagnetic fluorescent Fe@C nanoparticles, electron microscopy, magnetic field.
Funding agency Grant number
Russian Foundation for Basic Research 18-03-00936
15-04-08550
Ministry of Education and Science of the Russian Federation PNR 5.13
Russian Science Foundation 17-15-01290
This study was supported by the Russian Foundation for Basic Research (grants 18-03-00936, 15-04-08550), Program of MSU development (PNR 5.13), Russian Science Foundation (17-15-01290) and IBiSA Electron Microscopy Facility of Francois Rabelais University.
Received: 09.05.2017
Revised: 12.09.2017
Bibliographic databases:
Document Type: Article
PACS: 68.37.Lp, 75.75.Cd
Language: English
Citation: A. S. Garanina, I. I. Kireev, I. B. Alieva, A. G. Majouga, V. A. Davydov, S. Murugesan, V. N. Khabashesku, V. N. Agafonov, R. E. Uzbekov, “New superparamagnetic fluorescent Fe@C-C$_5$ON$_2$H$_{10}$-Alexa Fluor 647 nanoparticles for biological applications”, Nanosystems: Physics, Chemistry, Mathematics, 9:1 (2018), 120–122
Citation in format AMSBIB
\Bibitem{GarKirAli18}
\by A.~S.~Garanina, I.~I.~Kireev, I.~B.~Alieva, A.~G.~Majouga, V.~A.~Davydov, S.~Murugesan, V.~N.~Khabashesku, V.~N.~Agafonov, R.~E.~Uzbekov
\paper New superparamagnetic fluorescent Fe@C-C$_5$ON$_2$H$_{10}$-Alexa Fluor 647 nanoparticles for biological applications
\jour Nanosystems: Physics, Chemistry, Mathematics
\yr 2018
\vol 9
\issue 1
\pages 120--122
\mathnet{http://mi.mathnet.ru/nano142}
\crossref{https://doi.org/10.17586/2220-8054-2018-9-1-120-122}
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