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CHEMISTRY AND MATERIAL SCIENCE
Cerium oxide@silica core-shell nanocomposite as multimodal platforms for drug release and synergistic anticancer effects
Elizaveta A. Zamyatinaa, Sergey Yu. Kottsovb, Viktoriia A. Anikinaa, Anton L. Popova, Marina P. Shevelyovac, Nelli R. Popovaa a Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences, Pushchino, Russia
b Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences, Moscow, Russia
c Institute for Biological Instrumentation of the Russian Academy of Sciences, Pushchino, Russia
Abstract:
Cerium oxide nanoparticles (CeNPs) are among the most promising materials with pH-sensitive redox-activity for biomedical nanotechnologies. CeNPs are known to reduce the toxicity of the chemotherapeutic drug doxorubicin (DOX) for normal cells. Here we have proposed and analyzed a new hybrid cerium/silica containing SiNPs@DOX@CeNPs nanocomposite. We showed that the average size of the nanocomposite is 190 nm and it has a spherical shape. The SiNPs@DOX@CeNPs nanocomposite provides effective synergistic anticancer activity of CeNPs with doxorubicin (DOX), as well as selective toxicity against human osteosarcoma (MNNG/HOS) cells in vitro. The SiNPs@DOX@CeNPs nanocomposite may be a good candidate to increase the effectiveness of cancer doxorubicin chemotherapy.
Keywords:
nanocomposites, silica nanoparticles, cerium oxide nanoparticles, biomedical application, characterization, drug delivery.
Received: 06.09.2023 Accepted: 11.09.2023
Citation:
Elizaveta A. Zamyatina, Sergey Yu. Kottsov, Viktoriia A. Anikina, Anton L. Popov, Marina P. Shevelyova, Nelli R. Popova, “Cerium oxide@silica core-shell nanocomposite as multimodal platforms for drug release and synergistic anticancer effects”, Nanosystems: Physics, Chemistry, Mathematics, 14:5 (2023), 560–570
Linking options:
https://www.mathnet.ru/eng/nano1223 https://www.mathnet.ru/eng/nano/v14/i5/p560
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Abstract page: | 67 | Full-text PDF : | 37 |
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