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Nanosystems: Physics, Chemistry, Mathematics, 2021, Volume 12, Issue 3, Pages 329–335
DOI: https://doi.org/10.17586/2220-8054-2021-12-3-329-335 (Mi nano1029) 		 
This article is cited in 2 scientific papers (total in 2 papers)

CHEMISTRY AND MATERIAL SCIENCE

Comprehensive cytotoxicity analysis of polysaccharide hydrogel modified with cerium oxide nanoparticles for wound healing application

A. L. Popovab, V. V. Andreevac, N. V. Khohlovd, K. A. Kamenskikha, V. B. Gavrilyuka, V. K. Ivanovb

a Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences, Institutskaya str., 3, Pushchino, 142290, Russia
b Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences, Leninskiy prosp., 31, Moscow, 119991, Russia
c Moscow Regional Research and Clinical Institute, Laboratory of Medical and Physics Research, Shchepkina str. 61/2, Moscow, 129110, Russia
d I. M. Sechenov First Moscow State Medical University, Bolshaya Pirogovskaya str., 19s1, Moscow, 119146, Russia
Full-text PDF (168 kB) Citations (2)
DOI: https://doi.org/10.17586/2220-8054-2021-12-3-329-335
Abstract: This paper is aimed at the experimental study (in animal models) of acute toxicity and irritating properties of polysaccharide hydrogel modified with cerium oxide nanoparticles. In the acute experiment, there were no indications of irritating action of the gel at the site of application when the hydrogel was administered intragastrically or epicutaneously. No lethal effects were registered during this experiment even at the highest concentration. The results obtained demonstrate the lack of acute toxicity and local irritability of the synthesized hybrid hydrogel, which allows to classify the developed hybrid hydrogel as the relatively low-risk drug.
Keywords: wound healing, hydrogel, cerium oxide nanoparticles, epicutaneous application, regeneration, cell proliferation.
Funding agency Grant number
Ministry of Education and Science of the Russian Federation MK-138.2020.3
Russian Foundation for Basic Research 19-34-90031
The reported study was funded by the grant of the President of the Russian Federation MK-138.2020.3. Synthesis of CeO$_2$-containing hydrogels was performed by K. Kamenskikh with the support from RFBR grant 19-34-90031.
Received: 13.05.2021
Bibliographic databases:
Document Type: Article
Language: English
Citation: A. L. Popov, V. V. Andreeva, N. V. Khohlov, K. A. Kamenskikh, V. B. Gavrilyuk, V. K. Ivanov, “Comprehensive cytotoxicity analysis of polysaccharide hydrogel modified with cerium oxide nanoparticles for wound healing application”, Nanosystems: Physics, Chemistry, Mathematics, 12:3 (2021), 329–335
Citation in format AMSBIB
\Bibitem{PopAndKho21}
\by A.~L.~Popov, V.~V.~Andreeva, N.~V.~Khohlov, K.~A.~Kamenskikh, V.~B.~Gavrilyuk, V.~K.~Ivanov
\paper Comprehensive cytotoxicity analysis of polysaccharide hydrogel modified with cerium oxide nanoparticles for wound healing application
\jour Nanosystems: Physics, Chemistry, Mathematics
\yr 2021
\vol 12
\issue 3
\pages 329--335
\mathnet{http://mi.mathnet.ru/nano1029}
\crossref{https://doi.org/10.17586/2220-8054-2021-12-3-329-335}
\isi{https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=Publons&SrcAuth=Publons_CEL&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=000668639600009}
\elib{https://elibrary.ru/item.asp?id=46222716}
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    • This publication is cited in the following 2 articles:
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