Matematicheskoe modelirovanie
RUS  ENG    JOURNALS   PEOPLE   ORGANISATIONS   CONFERENCES   SEMINARS   VIDEO LIBRARY   PACKAGE AMSBIB  
General information
Latest issue
Archive
Impact factor

Search papers
Search references

RSS
Latest issue
Current issues
Archive issues
What is RSS


Matem. Mod.:
Year:
Volume:
Issue:
Page:
Find




Personal entry:
Login:
Password:
Save password
Enter
Forgotten password?
Register

Matematicheskoe modelirovanie, 2014, Volume 26, Number 11, Pages 105–122 (Mi mm3548)  
This article is cited in 8 scientific papers (total in 8 papers)

Numerical simulation of ultradian oscillations in p53-Mdm2-network under stress conditions

O. F. Voropaevaab, S. R. Senchukovac, K. V. Brodtb, K. E. Garbuzovb, A. V. Melnitchenkob, A. A. Starikovab

a Institute of Computational Technologies, Siberian Branch of the Russian Academy of Sciences
b Novosibirsk State University
c Institute of Regional Pathology and Pathomorphology, Siberian Branch of the Russian Academy of Medical Sciences
Full-text PDF (559 kB) Citations (8)
References:
PDF
HTML
Abstract: The numerical analysis of the solutions of the equations system describing the dynamics of concentrations of proteins p53 and Mdm2 in their interaction has been executed. A detailed numerical investigation of the p53-Mdm2-network in the basal and stress conditions was carried out. Calculations showed that the mathematical model predicts a threat of uncontrolled apoptosis and also the possibility of excessive suppression of apoptosis, which increases the risk of tumors. We studied in detail the mechanism of control of the system under stress conditions.
Keywords: p53-induced apoptosis, p53-Mdm2-network, delay differential equation, numerical simulation, Andronov–Hopf bifurcation.
Received: 30.09.2013
English version:
Mathematical Models and Computer Simulations, 2015, Volume 7, Issue 3, Pages 281–293
DOI: https://doi.org/10.1134/S2070048215030102
Bibliographic databases:
Document Type: Article
UDC: 519.6; 519.8; 51-7; 616
Language: Russian
Citation: O. F. Voropaeva, S. R. Senchukova, K. V. Brodt, K. E. Garbuzov, A. V. Melnitchenko, A. A. Starikova, “Numerical simulation of ultradian oscillations in p53-Mdm2-network under stress conditions”, Matem. Mod., 26:11 (2014), 105–122; Math. Models Comput. Simul., 7:3 (2015), 281–293
Citation in format AMSBIB
\Bibitem{VorSenBro14}
\by O.~F.~Voropaeva, S.~R.~Senchukova, K.~V.~Brodt, K.~E.~Garbuzov, A.~V.~Melnitchenko, A.~A.~Starikova
\paper Numerical simulation of ultradian oscillations in p53-Mdm2-network under stress conditions
\jour Matem. Mod.
\yr 2014
\vol 26
\issue 11
\pages 105--122
\mathnet{http://mi.mathnet.ru/mm3548}
\mathscinet{http://mathscinet.ams.org/mathscinet-getitem?mr=3541384}
\elib{https://elibrary.ru/item.asp?id=23421448}
\transl
\jour Math. Models Comput. Simul.
\yr 2015
\vol 7
\issue 3
\pages 281--293
\crossref{https://doi.org/10.1134/S2070048215030102}
\scopus{https://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84930675972}
Linking options:
  • https://www.mathnet.ru/eng/mm3548
  • https://www.mathnet.ru/eng/mm/v26/i11/p105
    • This publication is cited in the following 8 articles:
    Citing articles in Google Scholar: Russian citations, English citations
    Related articles in Google Scholar: Russian articles, English articles
    		Математическое моделирование
    Statistics & downloads:
    Abstract page:312
    Full-text PDF :115
    References:30
    First page:7
     
      Contact us:
    		  Terms of Use  Registration to the website  Logotypes © Steklov Mathematical Institute RAS, 2024