Investigation of the model of tRNA secondary structure folding process

The results of computer simulation of RNA linear molecules folding into secondary structure are presented. The structure is formed in the course of two interacting processes: the molecular growth (sequential growth of the RNA molecular chain) and the structurization (gradual sequential secondary structure growth in the scope of developed molecular chain region). In the course of structurization the secondary structure develops through sequential addition of elementary substructures. In this case we have local minimization of free energy increment on a set of compatible stems. The calculation algorithms have been developed that caused the hundredfold increase of calculation speed. That algorithms use have made possible the structure folding investigation for full set of tRNA molecules, which was known in the world by the beginning of 1990. The solutions have been analysed on two-parameters region. Their assymmetry have been found with respect to the molecular chain growth direction. The greatest average percentage of tRNA secondary structure prediction (more than 86%) have been received for used free energy models.