Abstract:
Five lipoic acid esters were synthesized, and their nanoforms based on copolymer Pluronic F68 and phosphatidylcholine were obtained. The most pronounced antioxidant effect on neutrophils activated by phorbol-12-myristate-13-acetate was shown by the nanodispersion containing the derivative of lipoic acid with hexane-1,6-diol, reducing the concentration of reactive oxygen species by 7.5 times.
Citation:
V. A. Shchelkonogov, A. M. Inshakova, A. V. Shipelova, O. A. Baranova, A. V. Chekanov, N. S. Shastina, E. Yu. Solov'eva, A. I. Fedin, “Nanoparticles of lipoic acid esters: preparation and antioxidant effect”, Mendeleev Commun., 31:4 (2021), 507–508
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https://www.mathnet.ru/eng/mendc971
https://www.mathnet.ru/eng/mendc/v31/i4/p507
This publication is cited in the following 3 articles:
Hai-Xia Xu, Na-Na Zheng, Yu-Cong Zou, Qing-Feng Zhang, “Synthesis of piceid lipoate and the effect and micro-mechanism of alpha-lipoic acid moiety on its antioxidant activity”, Food Research International, 200 (2025), 115453
A. M. Inshakova, V. A. Shchelkonogov, N. S. Shastina, A. V. Chekanov, O. A. Baranova, M. O. Sokolova, A. K. Ivanova, A. I. Fedin, E. Yu. Solov'eva, “Antioxidant and antiplatelet effect of nanodispersions with conjugate of glutathione and lipoic acid”, Mendeleev Commun., 34:6 (2024), 887–889
V. A. Shchelkonogov, A. M. Inshakova, E. S. Darnotuk, A. V. Shipelova, A. V. Chekanov, O. A. Baranova, N. S. Shastina, E. Yu. Solov'eva, A. I. Fedin, “Effect of Nanodispersions with Lipoic Acid and Its Esters on the Functional Activity of Neutrophils and Platelets”, Russ J Bioorg Chem, 49:6 (2023), 1319