Abstract:
Base-promoted intramolecular aldol condensation of diastereomeric Michael adducts of levoglucosenone and cyclododecanone affords 12-hydroxy-14,20-dioxatetra-cyclo[9.6.1.112,17.113,16]icosan-18-one as a mixture of three diastereomers. The products thus obtained are promising for synthesizing 14-membered macrocyclic compounds, including cembranoids and their analogues.
Citation:
L. Kh. Faizullina, Yu. A. Khalilova, F. A. Valeev, “Intramolecular aldol condensation of Michael adducts of levoglucosenone and cyclododecanone”, Mendeleev Commun., 31:4 (2021), 493–494
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https://www.mathnet.ru/eng/mendc966
https://www.mathnet.ru/eng/mendc/v31/i4/p493
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