Abstract:
Reflux of two isomeric 3-amino-4,4,4-trifluoro-1-(2-pyridyl)but-2-en-1-one and 3-amino-1,1,1-trifluoro-4-(2-pyridyl)-but-3-en-2-one in acetic acid affords 4′-trifluoromethyl-2,2′:6′,2″-terpyridine (37%) with 1.4% admixture of 6′-trifluoromethyl-2,2′:4′,2″-terpyridine.
Citation:
V. I. Filyakova, N. S. Boltacheva, M. G. Pervova, V. N. Charushin, “A new synthesis of 4′-trifluoromethyl-2,2′:6′,2″-terpyridine”, Mendeleev Commun., 31:3 (2021), 388–389
Linking options:
https://www.mathnet.ru/eng/mendc939
https://www.mathnet.ru/eng/mendc/v31/i3/p388
This publication is cited in the following 2 articles:
V. I. Filyakova, N. S. Boltacheva, M. G. Pervova, V. N. Charushin, “Synthesis of 4′-trifluoromethyl- and 4′-difluoromethyl-2,2′:6′,2″-terpyridines”, Russ Chem Bull, 73:6 (2024), 1709
A. B. Koldobskii, O. S. Shilova, S. A. Glazun, I. V. Sandulenko, “Synthesis of polyfunctional trifluoromethylated pyridones fused with the strained carbocyclic cores”, Russ Chem Bull, 71:10 (2022), 2224
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