Abstract:
Deprotonation of diethyl (ethoxycarbonylmethyl)-phosphonate with NaH followed by treatment with acyl chlorides affords surprisingly the corresponding C,C-diacylated derivatives as the predominating products.
Citation:
K. V. Gulyás, G. T. Keglevich, “The surprising diacylation of diethyl (ethoxycarbonylmethyl)phosphonate”, Mendeleev Commun., 31:2 (2021), 244–245
Linking options:
https://www.mathnet.ru/eng/mendc893
https://www.mathnet.ru/eng/mendc/v31/i2/p244
This publication is cited in the following 2 articles:
Zsuzsanna Szalai, Boldizsár Tóth, Rita Oláhné Szabó, Szilvia Bősze, Konstantin Karaghiosoff, Mátyás Czugler, László Drahos, György Keglevich, “A Study of the Bisphosphonic Derivatives from the Pudovik Reaction of Dialkyl α-Oxophosphonates and >P(O)H Reagents: X-ray Structure and Bioactivity”, Molecules, 28:16 (2023), 6037
György Keglevich, Zsuzsanna Szalai, Kinga V. Gulyás, Róbert Zahár, Alajos Grün, Csilla Sepsey Für, “The synthesis of hydroxymethylenebisphosphonic- (dronic-) and acyl-ethoxycarbonyl-methylphosphonate derivatives”, Phosphorus, Sulfur, and Silicon and the Related Elements, 197:5-6 (2022), 520
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