Abstract:
Bisamides of 1,4-bis(aminomethyl)benzene with cyclopropane-, cyclobutane- and cyclopentanecarboxylic acids reveal the negative modulation of kainate-induced currents in rat Purkinje neurons observed using patch clamp technique. The most pronounced effect has been found for the bisamide of cyclobutanecarboxylic acid, which blocks the currents by 41 and 49% at concentrations of 1×10−10 and 1×10−9moldm−3, respectively.
Citation:
N. S. Temnyakova, D. A. Vasilenko, M. I. Lavrov, D. S. Karlov, Yu. K. Grishin, V. L. Zamoyski, V. V. Grigoriev, E. B. Averina, V. A. Palyulin, “New nanomolar negative modulators of AMPA receptors”, Mendeleev Commun., 31:2 (2021), 219–220
Linking options:
https://www.mathnet.ru/eng/mendc884
https://www.mathnet.ru/eng/mendc/v31/i2/p219
This publication is cited in the following 4 articles:
Elena A. Golubeva, Mstislav I. Lavrov, Eugene V. Radchenko, Vladimir A. Palyulin, “Diversity of AMPA Receptor Ligands: Chemotypes, Binding Modes, Mechanisms of Action, and Therapeutic Effects”, Biomolecules, 13:1 (2022), 56
V. Kh. Akparov, V. I. Timofeev, K. N. Koliasnikova, “The neuropeptide cycloprolylglycine can form a complex with AMPA receptors”, Mendeleev Commun., 32:4 (2022), 436–438
M. I. Lavrov, P. N. Veremeeva, E. A. Golubeva, E. V. Radchenko, V. L. Zamoyski, V. V. Grigoriev, V. A. Palyulin, “Positive and negative AMPA receptor modulators based on tricyclic bispidine derivative: Minor structural change inverts the type of activity”, Mendeleev Commun., 32:3 (2022), 360–363
E.V. Radchenko, A.S. Tarakanova, D.S. Karlov, M.I. Lavrov, V.A. Palyulin, “Ligands of the AMPA-subtype glutamate receptors: mechanisms of action and novel chemotypes”, BIOMED KHIM, 67:3 (2021), 187
Contact us: