Abstract:
A simple and effective protocol for the synthesis of 2H-pyrazolo[3,4-d]pyridazine 5,6-dioxides includes a transformation of accessible 3,4-diacetyl-5-methyl-1H-pyrazoles into the corresponding 1,4-dioximes followed by their N2O4- mediated oxidative cyclization. All transformations proceed under mild conditions in good to high yields. According to the Griess assay, synthesized 2H-pyrazolo[3,4-d]pyridazine 5,6-dioxides showed promising NO-donor profiles producing NO in a wide range of concentrations.
Citation:
A. S. Kulikov, M. A. Epishina, E. S. Zhilin, A. D. Shuvaev, L. L. Fershtat, N. N. Makhova, “Design and synthesis of pyrazolo[3,4-d]pyridazine 5,6-dioxides as novel NO-donors”, Mendeleev Commun., 31:1 (2021), 42–45
Linking options:
https://www.mathnet.ru/eng/mendc828
https://www.mathnet.ru/eng/mendc/v31/i1/p42
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