Abstract:
A three-component tandem protocol involving the reactions of bis(benzohydrazides), aromatic aldehydes and chloramine trihydrate yielded a new series of bis(1,3,4-oxadiazoles). The target hybrids were formed by an initial bis(N-benzoyl-hydrazones) formation, followed by chloramine trihydrate- mediated oxidative cyclization. The 4-methoxyphenyl-containing compounds demonstrated promising antibacterial activity against the Staphylococcus aureus and Pseudomonas aeruginosa strains with MIC value of 1.6 µm.
Keywords:N-acylhydrazones, benzohydrazide, chloramine trihydrate, intramolecular cyclization, in vitro antibacterial screening, multicomponent reactions, 1,3,4-oxadiazoles, oxidative cyclization, SwissADME prediction study, tandem reactions.
Citation:
A. E. Mekky, Sh. M. Sanad, A. M. Abdelfattah, “Tandem synthesis, antibacterial evaluation and SwissADME prediction study of new bis(1,3,4-oxadiazoles) linked to arene units”, Mendeleev Commun., 32:5 (2022), 612–614
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https://www.mathnet.ru/eng/mendc742
https://www.mathnet.ru/eng/mendc/v32/i5/p612
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Sherif M. H. Sanad, Ahmed E. M. Mekky, “Three-component regioselective synthesis and antibacterial evaluation of new arene-linked bis(pyrazolo[1,5-a]pyrimidine) hybrids”, Synthetic Communications, 53:9 (2023), 658
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Ahmed E. M. Mekky, Nariman A. S. Taha, Nada G. Mohammed, Fatma R. M. Hussein, Esraa H. Abdelfattah, Aya A. Gamal Eldin, Alshimaa A. M. Abdelsalam, Sherif M. H. Sanad, “Development of pyrazolo[1,5-a]pyrimidine-based antibacterial agents”, Synthetic Communications, 53:13 (2023), 1053
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