V. V. Spiridonov, K. S. Sadovnikov, D. A. Vasilenko, K. N. Sedenkova, A. R. Lukmanova, A. A. Markova, A. V. Shibaeva, A. V. Bolshakova, S. S. Karlov, E. B. Averina, A. A. Yaroslavov, “Synthesis and evaluation of the anticancer activity of the water-dispersible complexes of 4-acylaminoisoxazole derivative with biocompatible nanocontainers based on Ca2+ (Mg2+) cross-linked alginate”, Mendeleev Commun., 32:5 (2022), 591

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Mendeleev Communications, 2022, Volume 32, Issue 5, Pages 591–593
DOI: https://doi.org/10.1016/j.mencom.2022.09.007 (Mi mendc735)

This article is cited in 6 scientific papers (total in 6 papers)

Communications

Synthesis and evaluation of the anticancer activity of the water-dispersible complexes of 4-acylaminoisoxazole derivative with biocompatible nanocontainers based on Ca²⁺ (Mg²⁺) cross-linked alginate

V. V. Spiridonov^a, K. S. Sadovnikov^a, D. A. Vasilenko^a, K. N. Sedenkova^a, A. R. Lukmanova^b, A. A. Markova^cd, A. V. Shibaeva^c, A. V. Bolshakova^a, S. S. Karlov^a, E. B. Averina^a, A. A. Yaroslavov^a

^a Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
^b Department of Materials Science, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
^c N.M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russian Federation
^d A.N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences, Moscow, Russian Federation

Full-text PDF (740 kB) Citations (6)

DOI: https://doi.org/10.1016/j.mencom.2022.09.007

Graphic abstract: Synthesis and evaluation of the anticancer activity of the water-dispersible complexes of 4-acylaminoisoxazole derivative with biocompatible nanocontainers based on Ca<sup>2+</sup> (Mg<sup>2+</sup>) cross-linked alginate

Abstract: Water-dispersible complexes of 4-methyl-N-[5-methyl-3-(3,4,5-trimethoxyphenyl)isoxazol-4-yl]benzamide possessing anticancer activity were prepared by its immobilization with biocompatible polymer nanocontainers based on sodium alginate cross-linked with Ca²⁺ and Mg²⁺ ions. It was found that this isoxazole derivative retains its structure during immobilization. Colloidal stable nanocontainers filled with this compound exhibit toxicity toward the colon carcinoma (HCT116) tumor cell line.

Keywords: polysaccharide nanocontainers, alginate, 4-acylaminoisoxazoles, colloidal stability, anticancer activity.

Document Type: Article

Language: English

*Supplementary materials:*
		Supplementary_data_1.pdf	(467.6 Kb)

Citation: V. V. Spiridonov, K. S. Sadovnikov, D. A. Vasilenko, K. N. Sedenkova, A. R. Lukmanova, A. A. Markova, A. V. Shibaeva, A. V. Bolshakova, S. S. Karlov, E. B. Averina, A. A. Yaroslavov, “Synthesis and evaluation of the anticancer activity of the water-dispersible complexes of 4-acylaminoisoxazole derivative with biocompatible nanocontainers based on Ca²⁺ (Mg²⁺) cross-linked alginate”, Mendeleev Commun., 32:5 (2022), 591–593

Linking options:

https://www.mathnet.ru/eng/mendc735

https://www.mathnet.ru/eng/mendc/v32/i5/p591

This publication is cited in the following 6 articles:

Tatyana V. Bogatova, Sergey S. Karlov, Nikolai V Lobanov, “ON THE 95TH ANNIVERSARY OF THE FACULTY OF CHEMISTRY OF MOSCOW STATE UNIVERSITY”, Lomonosov chemistry journal, 66:№1, 2025 (2025), 3
D. G. Sinelnikova, O. A. Novoskoltseva, N. G. Loiko, Yu. A. Nikolaev, A. A. Yaroslavov, “Hybrid polycomplexes of anionic alginate with a synthetic cationic polymer: attractive and poisonous for microorganisms”, Mendeleev Commun., 34:1 (2024), 31–33
M. M. Efremova, D. D. Khashimova, N. S. Kalinin, A. A. Shtyrov, M. N. Ryazantsev, D. V. Spiridonova, A. I. Govdi, I. A. Balova, “Microwave assisted cycloaddition of benzonitrile oxides to 1-iodobuta-1,3-diynes”, Mendeleev Commun., 34:4 (2024), 536–539
Kseniya N. Sedenkova, Denis N. Leschukov, Yuri K. Grishin, Nikolay A. Zefirov, Yulia A. Gracheva, Dmitry A. Skvortsov, Yanislav S. Hrytseniuk, Lilja A. Vasilyeva, Elena A. Spirkova, Pavel N. Shevtsov, Elena F. Shevtsova, Alina R. Lukmanova, Vasily V. Spiridonov, Alina A. Markova, Minh T. Nguyen, Alexander A. Shtil, Olga N. Zefirova, Alexander A. Yaroslavov, Elena R. Milaeva, Elena B. Averina, “Verubulin (Azixa) Analogues with Increased Saturation: Synthesis, SAR and Encapsulation in Biocompatible Nanocontainers Based on Ca2+ or Mg2+ Cross-Linked Alginate”, Pharmaceuticals, 16:10 (2023), 1499
V. V. Spiridonov, A. R. Lukmanova, D. V. Pozdyshev, A. A. Markova, Yu. L. Volodina, G. V. Golovina, V. V. Shakhmatov, V. A. Kuzmin, V. I. Muronetz, A. A. Yaroslavov, “Ionically cross-linked micro-sized hydrogels with encapsulated drug: Structure, cell uptake kinetics and cytotoxicity”, Mendeleev Commun., 33:4 (2023), 553–555
S. V. Kurmaz, I. I. Ivanova, N. S. Emelyanova, D. V. Konev, V. A. Kurmaz, N. V. Filatova, A. A. Balakina, A. A. Terentyev, “Doxorubicin compositions with biocompatible terpolymer of N-vinylpyrrolidone, methacrylic acid and triethylene glycol dimethacrylate”, Mendeleev Commun., 33:2 (2023), 255–258

Citing articles in Google Scholar: Russian citations, English citations
Related articles in Google Scholar: Russian articles, English articles

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