E. G. Paronikyan, A. G. Ayvazyan, S. S. Mamyan, Sh. Sh. Dashyan, “New synthesis of 6,8-diamino-substituted pyrano[3,4-c]pyridines from related pyrano[3,4-c]pyridin-6-one”, Mendeleev Commun., 34:1 (2024), 129

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Mendeleev Communications, 2024, Volume 34, Issue 1, Pages 129–130
DOI: https://doi.org/10.1016/j.mencom.2024.01.039 (Mi mendc64)

Communications

New synthesis of 6,8-diamino-substituted pyrano[3,4-c]pyridines from related pyrano[3,4-c]pyridin-6-one

E. G. Paronikyan, A. G. Ayvazyan, S. S. Mamyan, Sh. Sh. Dashyan

Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia, Yerevan, Armenia

Full-text PDF (286 kB)

DOI: https://doi.org/10.1016/j.mencom.2024.01.039

Graphic abstract: New synthesis of 6,8-diamino-substituted pyrano[3,4-<i>c</i>]pyridines from related pyrano[3,4-<i>c</i>]pyridin-6-one

Abstract: The tosylation of 3,3-dimethyl-8-(morpholin-4-yl)-6-oxo-3,4,6,7-tetrahydro-1H-pyrano[3,4-c]pyridine-5-carbonitrile with TsCl occurs at the oxo group of the NH-lactam moiety. The subsequent nucleophilic displacement of O-tosylate by various amines affords the title compounds in good yields.

Keywords: pyrano[3,4-c]pyridines, p-toluenesulfonyl chloride, alkylation, regioselectivity, O-tosylate, amines.

Document Type: Article

Language: English

*Supplementary materials:*
		Supplementary_data_1.pdf	(2.1 Mb)

Citation: E. G. Paronikyan, A. G. Ayvazyan, S. S. Mamyan, Sh. Sh. Dashyan, “New synthesis of 6,8-diamino-substituted pyrano[3,4-c]pyridines from related pyrano[3,4-c]pyridin-6-one”, Mendeleev Commun., 34:1 (2024), 129–130

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Citing articles in Google Scholar: Russian citations, English citations
Related articles in Google Scholar: Russian articles, English articles

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