Abstract:
An efficient and selective access to novel α-CF3-substituted γ,δ-didehydro lysine derivatives and their phosphorus analogues has been developed via the Cu-catalyzed Mannich reaction of α-amino α-propargyl α-trifluoromethyl carboxylates or phosphonates with different secondary amines and paraformaldehyde.
Citation:
A. N. Philippova, D. V. Vorobyeva, T. P. Vasilyeva, A. K. Mailyan, P. S. Gribanov, S. N. Osipov, “Synthesis of α-CF3-substituted γ,δ-didehydro lysine derivatives”, Mendeleev Commun., 32:2 (2022), 260–261
Linking options:
https://www.mathnet.ru/eng/mendc633
https://www.mathnet.ru/eng/mendc/v32/i2/p260
This publication is cited in the following 3 articles:
Kevin Van holsbeeck, Mathias Elsocht, Steven Ballet, “Propargylamine Amino Acids as Constrained Nε-Substituted Lysine Mimetics”, Org. Lett., 25:1 (2023), 130
S. A. Runikhina, A. A. Tsygankov, O. I. Afanasyev, D. A. Chusov, “Reductive α-alkylation of ketones with aldehydes at atmospheric pressure of carbon monoxide: the effect of fluoride activation in ruthenium catalysis”, Mendeleev Commun., 33:1 (2023), 17–20
A. S. Kozlov, O. I. Afanasyev, M. A. Losev, M. I. Godovikova, D. A. Chusov, “Nitrogen ligand influence on the CO-assisted ruthenium-catalyzed reductive amination”, Mendeleev Commun., 33:2 (2023), 174–176
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