Abstract:
Alkylcobalt chelates possessing tridentate Schiff bases display nuclease activity upon proton-assisted homolytic decomposition, due to the formation of both alkyl free radicals and a cobalt complex catalysing the autooxidation of organic substrates.
Document Type:
Article
Language: English
Citation:
I. Ya. Levitin, V. M. Belkov, G. N. Novodarova, Z. A. Shabarova, M. E. Vol'pin, “Synthetic nucleases triggered by mild acidification: a new type of biologically active compounds”, Mendeleev Commun., 6:4 (1996), 153–154
Linking options:
https://www.mathnet.ru/eng/mendc4957
https://www.mathnet.ru/eng/mendc/v6/i4/p153
This publication is cited in the following 6 articles:
Wang-Yong Yang, Boris Breiner, Serguei V. Kovalenko, Chi Ben, Mani Singh, Shauna N. LeGrand, Qing-Xiang Amy Sang, Geoffrey F. Strouse, John A. Copland, Igor V. Alabugin, “C-Lysine Conjugates: pH-Controlled Light-Activated Reagents for Efficient Double-Stranded DNA Cleavage with Implications for Cancer Therapy”, J. Am. Chem. Soc., 131:32 (2009), 11458
Amit Basak, Moumita Kar, Subrata Mandal, “Dependence of reactivity of a novel 2,6-diamino pyridine-based enediyne on the extent of salt formation with external acids: a possible implication in pH based drug design”, Bioorganic & Medicinal Chemistry Letters, 15:8 (2005), 2061
Pavel Nesterenko, Ilia Levitin, Nina Chernoglazova, Elena Paskonova, Natalia Penner, Marina Tsikalova, “Electrophoretic study of cationic cobalt(III) complexes with [N2O] and [N2O2] Schiff base ligands”, Inorganica Chimica Acta, 280:1-2 (1998), 295
Ilia Levitin, Vladimir Shur, “Mark Vol'pin: glorious path in science”, Inorganica Chimica Acta, 280:1-2 (1998), xv
Mark Vol'pin, Ilia Levitin, Sergei Osinsky, “New Course in the Search for Antitumor Agents: The Use of pH‐Dependent Sources of Reactive Radicals”, Angew. Chem. Int. Ed. Engl., 35:20 (1996), 2395
Mark Vol'Pin, Ilia Levitin, Sergei Osinsky, “Die pH‐abhängige Erzeugung reaktiver Radikale – neue Methoden zur Tumorbekämpfung**”, Angewandte Chemie, 108:20 (1996), 2516
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