Abstract:
The efficiency of two strategies for the synthesis of N-(2-aminophenyl)-5-nitrobenzimidazole derivatives was studied. The promising route involves the stages of 1-(2,4-dinitro-phenyl)-1H-benzimidazole monoreduction at 2-positioned nitro group and tandem conversion involving recyclization of the intermediate N-(2-amino-4-nitrophenyl)-5-nitrobenz-imidazole.
Citation:
R. S. Begunov, A. V. Chetvertakova, M. E. Neganova, “Regioselective synthesis of 2-(1H-benzimidazol-1-yl)-5-nitro- and 2-(5-nitro-1H-benzimidazol-1-yl)anilines”, Mendeleev Commun., 33:5 (2023), 650–652
Linking options:
https://www.mathnet.ru/eng/mendc485
https://www.mathnet.ru/eng/mendc/v33/i5/p650
This publication is cited in the following 4 articles:
A. S. Konstantinova, A. A. Shetnev, A. V. Semenov, S. I. Presnukhina, A. A. Romanycheva, A. S. Volobueva, V. V. Zarubaev, S. V. Baykov, M. K. Korsakov, “N-Arylamino-1,2,4-oxadiazol-5(4H)-ones: Synthesis, Luminescent, Antibacterial, and Antienteroviral Properties”, Russ J Gen Chem, 94:S1 (2024), S91
Roman Begunov, Luisa Savina, Alexander Khlopotinin, “Main and by-processes at 1-(2-nitroaryl)-1H-benzotriazole reduction”, From Chemistry Towards Technology Step-By-Step, 5:1 (2024), 33
Yulia R. Aleksandrova, Natalia S. Nikolaeva, Inna A. Shagina, Karina D. Smirnova, Alla A. Zubishina, Alexander I. Khlopotinin, Artem N. Fakhrutdinov, Alexander L. Khokhlov, Roman S. Begunov, Margarita E. Neganova, “N-Aryl Benzimidazole and Benzotriazole Derivatives and Their Hybrids as Cytotoxic Agents: Design, Synthesis and Structure–Activity Relationship Studies”, Molecules, 29:22 (2024), 5360
Roman Begunov, Luisa Savina, Alexander Khlopotinin, “Main and by-processes at 1-(2-nitroaryl)-1H-benzotriazole reduction”, From Chemistry Towards Technology Step-By-Step, 5:1 (2024), 107
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