Abstract:N-(Methoxycarbonyl)trihaloacetimidoylchlorides react with 5-aminopyrazoles under mild conditions to give N-methoxycarbonyl- N’-(5-pyrazolyl)trihaloacetamidines, which furnish 6-trihalomethyl-4H-pyrazolo[3,4-d]pyrimidin-4-ones by thermal intramolecular cyclocondensation.
Document Type:
Article
Language: English
Citation:
M. V. Vovk, A. V. Bol'but, V. I. Boiko, V. V. Pirozhenko, A. N. Chernega, “Synthesis of 1,5-dihydro-3-methyl-6-trihalomethyl-4H-pyrazolo[3,4-d]pyrimidin-4-ones”, Mendeleev Commun., 11:5 (2001), 198–199
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N. V. Mel'nichenko, V. N. Tkachuk, E. B. Rusanov, V. A. Sukach, V. I. Boiko, M. V. Vovk, “N-Benzyloxycarbonyl-2,2,2-trifluoroacetimidoyl chloride—A convenient reagent for the synthesis of 2-trifluoromethyl-4H-pyrido[1,2-a][1,3,5]triazin-4-one”, Russ J Org Chem, 49:1 (2013), 119
Volodymyr A. Sukach, Viktor M. Tkachuk, Eduard B. Rusanov, Gerd-Volker Röschenthaler, Mykhaylo V. Vovk, “Heterocyclization of N-(1-chloro-2,2,2-trifluoroethylidene)carbamates with β-enaminoesters—a novel synthetic strategy to functionalized trifluoromethylated pyrimidines”, Tetrahedron, 68:40 (2012), 8408
M. O. Lozinskii, A. Y. Il'chenko, “Chemistry of heterocyclic compounds at the Institute of Organic Chemistry, National Academy of Sciences of Ukraine (Review)”, Chem Heterocycl Comp, 45:4 (2009), 376
Mikhail V. Vovk, Andrei V. Bol'but, Vyacheslav I. Boiko, Vladimir V. Pirozhenko, Aleksandr N. Chernega, “ChemInform Abstract: Synthesis of 1,5‐Dihydro‐3‐methyl‐6‐trihalomethyl‐4H‐pyrazolo [3,4‐d]pyrimidin‐4‐ones.”, ChemInform, 33:11 (2002)
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