Abstract:
It has been shown theoretically using a parabolic model of radical reactions that alkyl radicals formed from artemisinin are involved in the rapid intramolecular chain oxidation of artemisinin to a polyfunctional initiator with several hydroperoxy groups.
Document Type:
Article
Language: English
Citation:
S. L. Solodova, E. T. Denisov, T. G. Denisova, “Artemisinin as a self-propagating radical initiator under aerobic conditions”, Mendeleev Commun., 18:1 (2008), 24–26
Linking options:
https://www.mathnet.ru/eng/mendc3234
https://www.mathnet.ru/eng/mendc/v18/i1/p24
This publication is cited in the following 10 articles:
E. T. Denisov, T. G. Denisova, “Kinetic analysis of free radical generation by peroxy, hydroxy, and alkoxy derivatives of 10-dihydroartemisinin”, Russ Chem Bull, 65:8 (2016), 2072
E. T. Denisov, T. G. Denisova, “Kinetic analysis of the hydroxyl mechanism of the antimalarial effect of fluorinated artemisinin derivatives”, Kinet Catal, 56:3 (2015), 285
E. T. Denisov, T. G. Denisova, “Generation of radicals and antimalarial activity of dispiro-1,2,4-trioxolanes”, Russ. J. Phys. Chem., 87:1 (2013), 10
E. T. Denisov, T. G. Denisova, “Mechanism of hydroxyl radical induced antimalarial action of hybrid analogues of 10-dihydroartemisinin”, Russ Chem Bull, 62:12 (2013), 2579
E. T. Denisov, T. G. Denisova, “Hydroxyl mechanism of the antimalarial action of dimeric analogues of artemisinin”, Kinet Catal, 54:1 (2013), 1
E. T. Denisov, T. G. Denisova, “Free-radical generation mechanism and antimalarial activity of cyclohexyl endoperoxides”, Kinet Catal, 53:2 (2012), 172
Evgeny Denisov, “An important role of intramolecular free radical reactions in antimalarial activity of artemisinin and its analogs”, Org. Biomol. Chem., 9:11 (2011), 4219
E. T. Denisov, T. G. Denisova, “Hydroxyl mechanism of the antimalarial effect of artemisinin and its analogs”, Russ Chem Bull, 60:7 (2011), 1421
E. T. Denisov, T. G. Denisova, “Generation of hydroxyl radicals by the intramolecular oxidation of tricyclic artemisinin analogs and their antimalarial activity”, Russ Chem Bull, 59:10 (2010), 1881
S. L. Solodova, E. T. Denisov, “Reactions of alkoxy and peroxy radicals formed upon the decomposition of hydroxyperoxide groups in the artemisinin derivatives”, Russ Chem Bull, 58:4 (2009), 777
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