Abstract:
A series of new furazan (1,2,5-oxadiazole) derivatives based on structural overlap with combretastatin have been synthesized. Targeted molecules were evaluated using the sea urchin embryo assay; several agents demonstrated 1–4μmol dm–3 antiproliferative activity in this in vivo model.
Citation:
A. B. Sheremetev, D. E. Dmitriev, N. K. Lagutina, M. M. Raikhshtat, A. S. Kiselev, M. N. Semenova, N. N. Ikizalp, V. V. Semenov, “New functionalized aminofurazans as potential antimitotic agents in the sea urchin embryo assay”, Mendeleev Commun., 20:3 (2010), 132–134
Linking options:
https://www.mathnet.ru/eng/mendc3013
https://www.mathnet.ru/eng/mendc/v20/i3/p132
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