Abstract:
Reaction of thiosemicarbazide with carboxylic acids, including N-substituted amino acids, in ionic liquids with H2SO4 as a catalyst affords 5-R-2-amino-1,3,4-thiadiazoles. On using alkanedicarboxylic acids, α,ω-bis(2-amino-1,3,4,-thiadiazol-5-yl)alkanes were obtained.
Citation:
M. A. Epishina, A. S. Kulikov, N. V. Ignat'ev, M. Schulte, N. N. Makhova, “Synthesis of 5-alkyl-2-amino-1,3,4-thiadiazoles and α,ω-bis(2-amino-1,3,4-thiadiazol-5-yl)alkanes in ionic liquids”, Mendeleev Commun., 21:6 (2011), 331–333
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