K. N. Sedenkova, S. V. Kositov, D. V. Zverev, E. V. Radchenko, Yu. K. Grishin, A. V. Gabrel'yan, V. L. Zamoyski, V. V. Grigoriev, E. B. Averina, V. A. Palyulin, “Novel AMPA receptor allosteric modulators of bis(pyrimidine) series: synthesis and SAR evaluation”, Mendeleev Commun., 34:1 (2024), 8

Loading [MathJax]/jax/output/SVG/config.js

Mendeleev Communications

RUS ENG

JOURNALS PEOPLE ORGANISATIONS CONFERENCES SEMINARS VIDEO LIBRARY PACKAGE AMSBIB

JavaScript is disabled in your browser. Please switch it on to enable full functionality of the website

	General information
	Latest issue
	Archive

	Search papers
	Search references

	RSS
	Latest issue
	Current issues
	Archive issues
	What is RSS

Mendeleev Commun.:
Year:
Volume:
Issue:
Page:
	Find

Personal entry:
Login:
Password:
	Save password
	Enter
	Forgotten password?
	Register

Mendeleev Communications, 2024, Volume 34, Issue 1, Pages 8–10
DOI: https://doi.org/10.1016/j.mencom.2024.01.002 (Mi mendc27)

Communications

Novel AMPA receptor allosteric modulators of bis(pyrimidine) series: synthesis and SAR evaluation

K. N. Sedenkova^a, S. V. Kositov^a, D. V. Zverev^a, E. V. Radchenko^a, Yu. K. Grishin^a, A. V. Gabrel'yan^b, V. L. Zamoyski^b, V. V. Grigoriev^ab, E. B. Averina^a, V. A. Palyulin^a

^a Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
^b Institute of Physiologically Active Compounds, Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russian Federation

Full-text PDF (863 kB)

DOI: https://doi.org/10.1016/j.mencom.2024.01.002

Graphic abstract: Novel AMPA receptor allosteric modulators of bis(pyrimidine) series: synthesis and SAR evaluation

Abstract: A series of new bis(pyrimidines) with p-hydroquinone linker was prepared and evaluated as AMPA receptor modulators. Both positive and negative modulators were found among the investigated compounds.

Keywords: pyrimidines, aromatic nucleophilic substitution, AMPA receptor, allosteric modulators, bivalent ligands.

Document Type: Article

Language: English

*Supplementary materials:*
		Supplementary_data_1.pdf	(1.3 Mb)

Citation: K. N. Sedenkova, S. V. Kositov, D. V. Zverev, E. V. Radchenko, Yu. K. Grishin, A. V. Gabrel'yan, V. L. Zamoyski, V. V. Grigoriev, E. B. Averina, V. A. Palyulin, “Novel AMPA receptor allosteric modulators of bis(pyrimidine) series: synthesis and SAR evaluation”, Mendeleev Commun., 34:1 (2024), 8–10

Linking options:

https://www.mathnet.ru/eng/mendc27

https://www.mathnet.ru/eng/mendc/v34/i1/p8

Citing articles in Google Scholar: Russian citations, English citations
Related articles in Google Scholar: Russian articles, English articles

Statistics & downloads:
Abstract page:	39
Full-text PDF :	14

Registration to the website

Logotypes