Abstract:
The measurement of the antiaggregant properties of 3-cyano-4-phenylfuroxan and 3-nitro-4-phenylfuroxan has demonstrated that these compounds effectively inhibit platelet agglutination induced by adenosine diphosphate and adrenaline but not ristocetin. When collagen was used as an inducer, only a slight delay of aggregate formation was observed. Therefore, these furoxan derivatives could be considered as a basis for the development of next generation agents with improved antiaggregant activity.
Document Type:
Article
Language: English
Citation:
N. E. Ustyuzhanina, L. L. Fershtat, M. L. Gening, N. E. Nifantiev, N. N. Makhova, “New insight into the antiaggregant activity of furoxans”, Mendeleev Commun., 26:6 (2016), 513–515
Linking options:
https://www.mathnet.ru/eng/mendc2264
https://www.mathnet.ru/eng/mendc/v26/i6/p513
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