Abstract:
Chemoenzymatic transglycosylation of 2-aminopurine conjugates with enantiomerically pure 7,8-difluoro-3-methyl-3,4-dihydro-2H-[1,4]benzoxazines under the action of recombinant E. coli purine nucleoside phosphorylase afforded the corresponding arabinofuranosides, yields of the target compounds being dependent on both the structure and configuration of the fragment of heterocyclic amine attached at C-6 position of purine moiety.
Citation:
B. Z. Eletskaya, I. D. Konstantinova, A. S. Paramonov, R. S. Esipov, D. A. Gruzdev, A. Yu. Vigorov, G. L. Levit, A. I. Miroshnikov, V. P. Krasnov, V. N. Charushin, “Chemoenzymatic arabinosylation of 2-aminopurines bearing the chiral fragment of 7,8-difluoro-3-methyl-3,4-dihydro-2H-[1,4]benzoxazines”, Mendeleev Commun., 26:1 (2016), 6–8
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https://www.mathnet.ru/eng/mendc2090
https://www.mathnet.ru/eng/mendc/v26/i1/p6
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