Abstract:
Hybrid molecules wherein five-membered rings of ferrocene or cymanthrene are covalently bonded with the amino group of daunorubicin through a methylene linker, have been synthesized by reductive amination of the corresponding aldehydes [M]C5H4CHO {[M] = CpFe or (CO)3Mn} using daunorubicin as an amine component.
Document Type:
Article
Language: English
Citation:
E. V. Sharova, O. I. Artyushin, N. V. Vinogradova, G. K. Genkina, V. K. Brel, “Synthesis of hybrid compounds composed of daunorubicin covalently linked with Cp2Fe and CpMn(CO)3”, Mendeleev Commun., 27:6 (2017), 608–609
Linking options:
https://www.mathnet.ru/eng/mendc2075
https://www.mathnet.ru/eng/mendc/v27/i6/p608
This publication is cited in the following 5 articles:
A. V. Semakov, “Low Molecular Weight Modifications of Anthracycline Antibiotics. Part I. Reactions by Amino Group (A Review)”, rev. and adv. in chem., 14:4 (2024), 345
Jeffrey S. Price, David J.H. Emslie, Comprehensive Organometallic Chemistry IV, 2022, 378
Aleksandra A. Moiseeva, Oleg I. Artyushin, Lada V. Anikina, Zinaida S. Klemenkova, Valery K. Brel, “N-Phosphorylation of daunorubicin—synthetic approaches and antiproliferative properties of the products”, Med Chem Res, 31:6 (2022), 1011
O. I. Artyushin, V. K. Brel, A. A. Moiseeva, “Synthesis of Daunorubicin Piperonal Derivatives by One-Step Reductive Amination”, Moscow Univ. Chem. Bull., 75:2 (2020), 106
Juan Oyarzo, Ramón Bosque, Patricia Toro, Carlos P. Silva, Rodrigo Arancibia, Mercè Font-Bardía, Vania Artigas, Carme Calvis, Ramon Messeguer, A. Hugo Klahn, Concepción López, “A novel type of organometallic 2-R-2,4-dihydro-1H-3,1-benzoxazine with R = [M(η5-C5H4)(CO)3] (M = Re or Mn) units. Experimental and computational studies of the effect of substituent R on ring-chain tautomerism”, Dalton Trans., 48:3 (2019), 1023
Contact us: