M. A. Khomutov, M. T. Hyvönen, A. R. Simonian, J. Weisell, J. J. Vepsalainen, L. Alhonen, S. N. Kochetkov, T. A. Keinanen, A. R. Khomutov, “Acetylated derivatives of C-methylated analogues of spermidine: synthesis and interaction with N1-acetylpolyamine oxidase”, Mendeleev Commun., 28:5 (2018), 479

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Mendeleev Communications, 2018, Volume 28, Issue 5, Pages 479–481
DOI: https://doi.org/10.1016/j.mencom.2018.09.008 (Mi mendc1806)

This article is cited in 5 scientific papers (total in 5 papers)

Communications

Acetylated derivatives of C-methylated analogues of spermidine: synthesis and interaction with N¹-acetylpolyamine oxidase

M. A. Khomutov^a, M. T. Hyvönen^b, A. R. Simonian^a, J. Weisell^b, J. J. Vepsalainen^b, L. Alhonen^b, S. N. Kochetkov^a, T. A. Keinanen^b, A. R. Khomutov^a

^a V.A. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russian Federation
^b School of Pharmacy, Biocenter Kuopio, University of Eastern Finland, Kuopio, Finland

Full-text PDF (276 kB) Citations (5)

DOI: https://doi.org/10.1016/j.mencom.2018.09.008

Graphic abstract: Acetylated derivatives of C-methylated analogues of spermidine: synthesis and interaction with <i>N</i><sup>1</sup>-acetylpolyamine oxidase

Abstract: The title compounds were prepared in high overall yields from properly protected (Boc, Cbz) 2- , 3- or 8-methyl-4-azaoctane-1,8-diamines. N¹-Acetyl-2-methyl- and N¹-acetyl-8-methylspermidines, but not N¹-acetyl-3-methylspermidine, were the substrates for N¹-acetylpolyamine oxidase.

Document Type: Article

Language: English

Citation: M. A. Khomutov, M. T. Hyvönen, A. R. Simonian, J. Weisell, J. J. Vepsalainen, L. Alhonen, S. N. Kochetkov, T. A. Keinanen, A. R. Khomutov, “Acetylated derivatives of C-methylated analogues of spermidine: synthesis and interaction with N¹-acetylpolyamine oxidase”, Mendeleev Commun., 28:5 (2018), 479–481

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https://www.mathnet.ru/eng/mendc1806

https://www.mathnet.ru/eng/mendc/v28/i5/p479

This publication is cited in the following 5 articles:

M. A. Khomutov, A. R. Khomutov, “Synthesis of 2-Methylidene Spermidine and its N1-Acetylated Derivative”, Russ J Bioorg Chem, 48:6 (2022), 1202
Maxim Khomutov, Mervi T. Hyvönen, Alina Simonian, Andrey A. Formanovsky, Irina V. Mikhura, Alexander O. Chizhov, Sergey N. Kochetkov, Leena Alhonen, Jouko Vepsäläinen, Tuomo A. Keinänen, Alex R. Khomutov, “Unforeseen Possibilities To Investigate the Regulation of Polyamine Metabolism Revealed by Novel C-Methylated Spermine Derivatives”, J. Med. Chem., 62:24 (2019), 11335
M. A. Khomutov, I. V. Mikhura, S. N. Kochetkov, A. R. Khomutov, “C-Methylated Analogs of Spermine and Spermidine: Synthesis and Biological Activity”, Russ J Bioorg Chem, 45:6 (2019), 463
K. A. Perevoshchikova, A. I. Nichugovskiy, A. K. Isagulieva, N. G. Morozova, I. V. Ivanov, M. A. Maslov, A. A. Shtil, “Synthesis of novel lipophilic tetraamines with cytotoxic activity”, Mendeleev Commun., 29:6 (2019), 616–618
M. A. Khomutov, A. O. Chizhov, S. N. Kochetkov, A. R. Khomutov, “Synthesis of (R)- and (S)-isomers of 2-methylspermidine”, Mendeleev Commun., 29:6 (2019), 678–679

Citing articles in Google Scholar: Russian citations, English citations
Related articles in Google Scholar: Russian articles, English articles

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