Abstract:
Magnesium iodide-catalyzed addition of electron-rich (het)arenes to ethyl glyoxylate proceeds at room temperature with high chemoselectivity to afford ethyl 2-(het)aryl- 2-hydroxyacetates in yields up to 95%.
Citation:
M. N. Feofanov, B. A. Lozhkin, M. V. Anokhin, A. D. Averin, I. P. Beletskaya, “Room temperature MgI2-catalyzed Friedel–Crafts reaction between electron-rich (het)arenes and ethyl glyoxylate”, Mendeleev Commun., 28:4 (2018), 429–430
Linking options:
https://www.mathnet.ru/eng/mendc1790
https://www.mathnet.ru/eng/mendc/v28/i4/p429
This publication is cited in the following 2 articles:
V. A. Egorov, F. A. Gimalova, Z. R. Zileeva, L. F. Zainullina, Yu. V. Vakhitova, M. S. Miftakhov, “2,3,5-Trichlorocyclopent-2-enone derivatives in the Friedel–Crafts reaction with methoxybenzenes and the anticancer activity of the products”, Mendeleev Commun., 29:2 (2019), 174–175
M. N. Feofanov, A. D. Averin, I. P. Beletskaya, “Friedel–Crafts reaction of electron-rich (het)arenes with nitroalkenes”, Mendeleev Commun., 29:2 (2019), 138–139
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