Abstract:
Multi-liposomal containers were prepared via electrostatic adsorption of 50 nm anionic liposomes on the surface of cationic chitosan nanoparticles (nanogels) 270 nm in diameter. The containers are stable in aqueous-salt solutions but degrade in the presence of proteolytic enzymes down to 10–15 nm particles and release water-soluble substances encapsulated into the adsorbed liposomes. Based on the kinetic data, the mechanism of the release is discussed.
Citation:
A. A. Yaroslavov, A. A. Efimova, F. D. Mulashkin, G. N. Rudenskaya, G. G. Krivtsov, “Biodegradable liposome–chitosan complexes: enzyme-mediated release of encapsulated substances”, Mendeleev Commun., 28:2 (2018), 140–142
Linking options:
https://www.mathnet.ru/eng/mendc1691
https://www.mathnet.ru/eng/mendc/v28/i2/p140
This publication is cited in the following 15 articles:
A. A. Efimova, T. A. Abramova, “Complexes of Anionic and Cationic Liposomes for Encapsulation of Bioactive Substances”, Russ J Gen Chem, 94:11 (2024), 3126
A. A. Efimova, T. A. Abramova, A. S. Popov, T. E. Grokhovskaya, “Interaction of Chitosan with Anionic Liquid Liposomes: Reversibility of Structural Rearrangements in Lipid Bilayer”, Russ J Gen Chem, 92:11 (2022), 2429
Dmitry V. Korolev, Galina A. Shulmeyster, Natalia V. Evreinova, Maria S. Syrovatkina, Maria S. Istomina, Victor N. Postnov, Ilia V. Aleksandrov, Aleksandr S. Krasichkov, Michael M. Galagudza, “Theranostic Platforms Based on Silica and Magnetic Nanoparticles Containing Quinacrine, Chitosan, Fluorophores, and Quantum Dots”, IJMS, 23:2 (2022), 932
A.A. Yaroslavov, A.A. Efimova, E.A. Krasnikov, K.S. Trosheva, A.S. Popov, N.S. Melik-Nubarov, G.G. Krivtsov, “Chitosan-based multi-liposomal complexes: Synthesis, biodegradability and cytotoxicity”, International Journal of Biological Macromolecules, 177 (2021), 455
A. A. Efimova, T. A. Abramova, A. S. Popov, “Complexes of Negatively Charged Liposomes with Chitosan: Effect of Phase State of the Lipid Bilayer”, Russ J Gen Chem, 91:10 (2021), 2079
A. S. Popov, A. A. Efimova, A. V. Kazantsev, D. A. Erzunov, N. V. Lukashev, I. D. Grozdova, N. S. Melik-Nubarov, A. A. Yaroslavov, “pH-Sensitive liposomes with embedded ampholytic derivatives of cholan-24-oic acid”, Mendeleev Commun., 31:6 (2021), 827–829
A. A. Efimova, A. S. Popov, G. G. Krivtsov, “Anionic Liposomes in Contact with Cationic Chitosan Particles”, Russ J Gen Chem, 90:11 (2020), 2156
Alexander Yaroslavov, Anna Efimova, Nataliya Smirnova, Dmitry Erzunov, Nikolay Lukashev, Irina Grozdova, Nikolay Melik-Nubarov, “A novel approach to a controlled opening of liposomes”, Colloids and Surfaces B: Biointerfaces, 190 (2020), 110906
Irina Grozdova, Nikolay Melik-Nubarov, Anna Efimova, Alexander Ezhov, George Krivtsov, Ekaterina Litmanovich, Alexander Yaroslavov, “Intracellular delivery of drugs by chitosan-based multi-liposomal complexes”, Colloids and Surfaces B: Biointerfaces, 193 (2020), 111062
M. V. Anakhov, R. A. Gumerov, I. I. Potemkin, “Stimuli-responsive aqueous microgels: properties and applications”, Mendeleev Commun., 30:5 (2020), 555–562
A. S. Kritchenkov, A. I. Kurachenkov, A. R. Egorov, N. Z. Yagafarov, E. A. Fortalnova, N. N. Lobanov, A. P. Dysin, A. S. Khomik, V. N. Khrustalev, “Novel zinc(II)/chitosan-based composite: ultrasound-assisted synthesis, catalytic and antibacterial activity”, Mendeleev Commun., 30:5 (2020), 642–644
A. A. Efimova, K. S. Trosheva, E. A. Krasnikov, G. G. Krivtsov, A. A. Yaroslavov, “Complexes of Anionic Cholesterol-Containing Liposomes and Cationic Chitosan Microparticles”, Polym. Sci. Ser. A, 61:6 (2019), 737
Z. G. Denieva, U. A. Budanova, Yu. L. Sebyakin, “Synthetic asymmetric lipid-like organosilanes for liposomal nanohybrid cerasomes toward potential medical applications”, Mendeleev Commun., 29:1 (2019), 32–34
D. V. Pryazhnikov, O. O. Efanova, I. V. Kubrakova, “Cerasomes containing magnetic nanoparticles: synthesis and gel-filtration chromatographic characterization”, Mendeleev Commun., 29:2 (2019), 226–228
N. E. Sedyakina, N. B. Feldman, S. V. Lutsenko, G. V. Avramenko, “Fabrication and drug release behavior of ionically cross-linked chitosan microspheres”, Mendeleev Commun., 28:6 (2018), 598–600
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