Abstract:
The herein developed phosphorus halide free synthesis of 1,2,3,4-tetrahydroisophosphinoline 2-oxides involves intramolecular heterocyclization of P,P-bis(2-arylethyl)-P-(α-hydroxybenzyl) phosphine oxides, available from styrenes, phosphine and aldehydes. The cyclization proceeds in the presence of FeCl3 at 80°C, yield of the products is 53–60%.
Citation:
S. F. Malysheva, N. K. Gusarova, N. A. Belogorlova, A. O. Sutyrina, A. I. Albanov, B. G. Sukhov, V. A. Kuimov, Yu. I. Litvintsev, B. A. Trofimov, “Phosphorus halide free synthesis of 1,2,3,4-tetrahydroisophosphinoline 2-oxides”, Mendeleev Commun., 28:1 (2018), 29–30
Linking options:
https://www.mathnet.ru/eng/mendc1652
https://www.mathnet.ru/eng/mendc/v28/i1/p29
This publication is cited in the following 3 articles:
Yu-Lin Hong, Yun Liu, Chang Wang, Xiu-Qing Fang, Feng Yang, Zhi-Wei Tan, Cheng-Mei Liu, “Progress in the preparation of phosphorus-containing polymers via phosphorus trichloride-free routes”, European Polymer Journal, 195 (2023), 112242
Thomas M. Hood, Samantha Lau, Ruth L. Webster, “Taming PH3: State of the Art and Future Directions in Synthesis”, J. Am. Chem. Soc., 144:37 (2022), 16684
M. V. Lesnichaya, S. F. Malysheva, N. A. Belogorlova, I. A. Graskova, A. V. Gazizova, A. I. Perfilyeva, O. A. Nozhkina, B. G. Sukhov, “Synthesis and antimicrobial activity of arabinogalactan-stabilized selenium nanoparticles from sodium bis(2-phenylethyl)diselenophosphinate”, Russ Chem Bull, 68:12 (2019), 2245
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