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Mendeleev Communications, 2024, Volume 34, Issue 4, Pages 496–498
DOI: https://doi.org/10.1016/j.mencom.2024.06.008
(Mi mendc165)
 

This article is cited in 1 scientific paper (total in 1 paper)

Communications

A metal-templated synthesis of precursors for (2S)- and (2R)-2-(3-[18F]fluoropropyl)tyrosines as potential radiotracers for positron emission tomography

T. F. Savel'yeva, Z. T. Gugkaeva, Yu. V. Nelyubina, A. F. Smol'yakov, M. A. Moskalenko, V. A. Larionov, V. I. Maleev

A.N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences, Moscow, Russian Federation
Full-text PDF (354 kB) Citations (1)
Abstract: New asymmetric metal-templated synthesis of enantiomers of (2S)- and (2R)-2-(3-[19F]fluoropropyl)tyrosine precursors were obtained based on a chiral NiII complex of the Schiff base derived from (S)-2-[N-(N’-benzylprolyl)amino]-benzaldehyde and racemic tyrosine in five steps. The free tyrosine derivatives which can be obtained upon decomplexation seem promising radiotracers for positron emission tomography imaging provided the introduction of 18F isotope.
Keywords: 18F-labelled amino acids, tyrosine, asymmetric synthesis, nucleophilic substitution, nickel(ii) complexes.
Document Type: Article
Language: English
Supplementary materials:
Supplementary_data_1.pdf (2.1 Mb)


Citation: T. F. Savel'yeva, Z. T. Gugkaeva, Yu. V. Nelyubina, A. F. Smol'yakov, M. A. Moskalenko, V. A. Larionov, V. I. Maleev, “A metal-templated synthesis of precursors for (2S)- and (2R)-2-(3-[18F]fluoropropyl)tyrosines as potential radiotracers for positron emission tomography”, Mendeleev Commun., 34:4 (2024), 496–498
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  • https://www.mathnet.ru/eng/mendc165
  • https://www.mathnet.ru/eng/mendc/v34/i4/p496
  • This publication is cited in the following 1 articles:
    1. Nadezhda V. Stoletova, Alexander F. Smol'yakov, Andrey A. Tyutyunov, Victor I. Maleev, Vladimir A. Larionov, “A Radical Hydrohaloalkylation of the Ligand Sphere of a Chiral Dehydroalanine Ni(II) Complex: An Asymmetric Route to Halogenated α-Amino Acid Derivatives”, Tetrahedron Chem, 2024, 100118  crossref
    Citing articles in Google Scholar: Russian citations, English citations
    Related articles in Google Scholar: Russian articles, English articles
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