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Mendeleev Communications, 2019, Volume 29, Issue 5, Pages 526–528
DOI: https://doi.org/10.1016/j.mencom.2019.09.016
(Mi mendc1579)
 

This article is cited in 1 scientific paper (total in 1 paper)

Communications

Synthesis of allobetulin-based asialoglycoprotein receptor-targeted glycoconjugates

E. I. Selezneva, E. Yu. Yamansarova, E. V. Lopatukhinaa, A. V. Lopuhova, D. A. Skvortsova, S. A. Evteeva, E. T. Yamansarovab, A. Yu. Adelgareevab, N. L. Klyachkoac, E. K. Beloglazkinaa, Ya. A. Ivanenkovde, A. G. Majougaafg

a Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
b Department of Chemistry, Bashkir State University, Ufa, Russian Federation
c Skolkovo Institute of Science and Technology, Moscow, Russian Federation
d Institute of Biochemistry and Genetics, Ufa Federal Research Center of the Russian Academy of Sciences, Ufa, Russian Federation
e Moscow Institute of Physics and Technology (National Research University), Dolgoprudny, Moscow Region, Russian Federation
f D.Mendeleev University of Chemical Technology of Russia, Moscow, Russian Federation
g National University of Science and Technology 'MISIS', Moscow, Russian Federation
Full-text PDF (209 kB) Citations (1)
Abstract: New allobetulin conjugates were obtained through its O-esterification with hex-5-ynoic acid followed by [3+2]-cycloaddition with three azido derivatives of N-acetyl-d-galactosamine. The conjugates are non-toxic in micromolar range against hepatocellular carcinoma cell lines and have a high affinity towards the HO asialoglycoprotein receptor of hepatocytes based on molecular docking and surface plasmon resonance data.
Document Type: Article
Language: English
Supplementary materials:
Supplementary_data_1.pdf (686.2 Kb)


Citation: E. I. Seleznev, E. Yu. Yamansarov, E. V. Lopatukhina, A. V. Lopuhov, D. A. Skvortsov, S. A. Evteev, E. T. Yamansarova, A. Yu. Adelgareeva, N. L. Klyachko, E. K. Beloglazkina, Ya. A. Ivanenkov, A. G. Majouga, “Synthesis of allobetulin-based asialoglycoprotein receptor-targeted glycoconjugates”, Mendeleev Commun., 29:5 (2019), 526–528
Linking options:
  • https://www.mathnet.ru/eng/mendc1579
  • https://www.mathnet.ru/eng/mendc/v29/i5/p526
  • This publication is cited in the following 1 articles:
    1. Emil Yu. Yamansarov, Elena V. Lopatukhina, Sergei A. Evteev, Dmitry A. Skvortsov, Anton V. Lopukhov, Sergey V. Kovalev, Alexander N. Vaneev, Dmitry O. Shkil', Roman A. Akasov, Alexander N. Lobov, Victor A. Naumenko, Ekaterina N. Pavlova, Oxana O. Ryabaya, Olga Yu. Burenina, Yan A. Ivanenkov, Natalia L. Klyachko, Alexander S. Erofeev, Petr V. Gorelkin, Elena K. Beloglazkina, Alexander G. Majouga, “Discovery of Bivalent GalNAc-Conjugated Betulin as a Potent ASGPR-Directed Agent against Hepatocellular Carcinoma”, Bioconjugate Chem., 32:4 (2021), 763  crossref
    Citing articles in Google Scholar: Russian citations, English citations
    Related articles in Google Scholar: Russian articles, English articles
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