Abstract:
A p-tert-butylthiacalix[4]arene derivative containing tryptophan moieties on the lower rim was synthesized and proposed as a chymotrypsin inhibitor. Its ability to competitively inhibit the enzyme was revealed by kinetic methods. A mechanism of the inhibitory action has been established, which consists in the binding of macrocycle tryptophan moieties to the enzyme active site, resulting in its blocking.
Citation:
O. A. Mostovaya, Yu. A. Valiullina, Ch. T. Chan, O. S. Potrekeeva, P. L. Padnya, Yu. F. Zuev, I. I. Stoikov, “Synthetic modulator of chymotrypsin activity based on p-tert-butylthiacalix[4]arene”, Mendeleev Commun., 29:5 (2019), 520–522
Linking options:
https://www.mathnet.ru/eng/mendc1577
https://www.mathnet.ru/eng/mendc/v29/i5/p520
This publication is cited in the following 7 articles:
Igor Shiabiev, Dmitry Pysin, Alexandra Kharlamova, Irina Zueva, Konstantin Petrov, Mikhail Bukharov, Olga Babaeva, Olga Mostovaya, Pavel Padnya, Ivan Stoikov, “Design of reversible cholinesterase inhibitors: Fine-tuning of enzymatic activity by PAMAM-calix-dendrimers”, International Journal of Biological Macromolecules, 2024, 138503
K. A. Kochetkov, M. A. Tsvetikova, O. N. Gorunova, N. A. Bystrova, V. S. Yufriakov, “Enantioselective synthesis of 5-fluoro-L-DOPA via chemoenzymatic route”, Mendeleev Commun., 34:1 (2024), 11–12
O. A. Mostovaya, A. A. Vavilova, I. I. Stoikov, “Supramolecular Systems Based on Thiacalixarene Derivatives and Biopolymers”, Colloid J, 84:5 (2022), 546
Luidmila Yakimova, Aisylu Kunafina, Olga Mostovaya, Pavel Padnya, Timur Mukhametzyanov, Alexandra Voloshina, Konstantin Petrov, Artur Boldyrev, Ivan Stoikov, “Albumin/Thiacalix[4]arene Nanoparticles as Potential Therapeutic Systems: Role of the Macrocycle for Stabilization of Monomeric Protein and Self-Assembly with Ciprofloxacin”, IJMS, 23:17 (2022), 10040
O.A. Mostovaya, P.L. Padnya, D.N. Shurpik, I.E. Shiabiev, I.I. Stoikov, “Novel lactide derivatives of p-tert-butylthiacalix[4]arene: Directed synthesis and molecular recognition of catecholamines”, Journal of Molecular Liquids, 327 (2021), 114806
I. S. Antipin, M. V. Alfimov, V. V. Arslanov, V. A. Burilov, S. Z. Vatsadze, Ya. Z. Voloshin, K. P. Volcho, V. V. Gorbatchuk, Yu. G. Gorbunova, S. P. Gromov, S. V. Dudkin, S. Yu. Zaitsev, L. Ya. Zakharova, M. A. Ziganshin, A. V. Zolotukhina, M. A. Kalinina, E. A. Karakhanov, R. R. Kashapov, O. I. Koifman, A. I. Konovalov, V. S. Korenev, A. L. Maksimov, N. Zh. Mamardashvili, G. M. Mamardashvili, A. G. Martynov, A. R. Mustafina, R. I. Nugmanov, A. S. Ovsyannikov, P. L. Padnya, A. S. Potapov, S. L. Selektor, M. N. Sokolov, S. E. Solovieva, I. I. Stoikov, P. A. Stuzhin, E. V. Suslov, E. N. Ushakov, V. P. Fedin, S. V. Fedorenko, O. A. Fedorova, Yu. V. Fedorov, S. N. Chvalun, A. Yu. Tsivadze, S. N. Shtykov, D. N. Shurpik, M. A. Shcherbina, L. S. Yakimova, “Functional supramolecular systems: design and applications”, Russian Chem. Reviews, 90:8 (2021), 895–1107
G. V. Zyryanov, D. S. Kopchuk, I. S. Kovalev, S. Santra, M. Rahman, A. F. Khasanov, A. P. Krinochkin, O. S. Taniya, O. N. Chupakhin, V. N. Charushin, “Rational synthetic methods in creating promising (hetero)aromatic molecules and materials”, Mendeleev Commun., 30:5 (2020), 537–554
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