Abstract:
Derivatives of natural lupenone, dipterocarpol, alnincanone and semisynthetic dipterocarpol lactone fused with pyrazine heterocycle along C2–C3 positions were obtained by the Willgerodt–Kindler reaction, X-ray analysis having been used for the structure identification. Anti-influenza and anti-proliferative activities of the compounds obtained were estimated.
Citation:
A. D. Zorina, N. S. Nikiforova, V. V. Zarubaev, S. A. Marchenko, S. I. Selivanov, G. L. Starova, A. R. Mehtiev, E. I. Rodionov, A. A. Rodionova, R. E. Trifonov, “Synthesis, structure and in vitro biological evaluation of new lupane and dammarane triterpenoids fused with pyrazine heterocycle”, Mendeleev Commun., 29:5 (2019), 500–502
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https://www.mathnet.ru/eng/mendc/v29/i5/p500
This publication is cited in the following 10 articles:
Shilpi Pathak, Neetu Agrawal, Sonam Gaur, “A Review on Diverse Biological Activity of Heterocyclic Nucleus Pyrazine
and its Derivatives: A Key for the Researchers”, LOC, 21:4 (2024), 351
E. I. Rodionov, A. A. Rodionova, A. D. Zorina, O. V. Khoroshilova, V. V. Suslonov, E. V. Lider, Yu. A. Golubeva, L. S. Klyushova, Yu. B. Porozov, N. N. Kuzmich, R. E. Trifonov, “Synthesis, structure and cytotoxicity of novel tetrazolo[1',5'-c]-fused 3-aza-A-homosteroids”, Mendeleev Commun., 34:4 (2024), 505–508
Guo-Qing Chen, Hong-Yan Guo, Zhe-Shan Quan, Qing-Kun Shen, Xiaoting Li, Tian Luan, “Natural Products–Pyrazine Hybrids: A Review of Developments in Medicinal Chemistry”, Molecules, 28:21 (2023), 7440
Fabiola A. López-Huerta, María Teresa Ramírez-Apan, Carlos A. Méndez-Cuesta, Antonio Nieto-Camacho, Simón Hernández-Ortega, Ericka K.P. Almeida-Aguirre, Marco A. Cerbón, Guillermo Delgado, “Synthesis, biological evaluation, molecular docking studies and In-silico ADMET evaluation of pyrazines of pentacyclic triterpenes”, Bioorganic Chemistry, 125 (2022), 105924
I. E. Smirnova, “Synthesis of 1,2,3-Thiadiazoles Fused to Dipterocarpol and Hollongdione”, Russ J Org Chem, 58:9 (2022), 1358
Mohammed Aarjane, Siham Slassi, Adib Ghaleb, Bouchra Tazi, Amina Amine, “Synthesis, biological evaluation, molecular docking and in silico ADMET screening studies of novel isoxazoline derivatives from acridone”, Arabian Journal of Chemistry, 14:4 (2021), 103057
Irina E. Smirnova, Oxana B. Kazakova, Anne Loesche, Sophie Hoenke, Rene Csuk, “Evaluation of cholinesterase inhibitory activity and cytotoxicity of synthetic derivatives of di- and triterpene metabolites from Pinus silvestris and Dipterocarpus alatus resins”, Med Chem Res, 29:8 (2020), 1478
Irina E. Smirnova, Tran Thi Phuong Thao, “Evaluation on antimicrobial potential of dipterocarpol and dammarenolic acid derivatives from Dipterocarpus alatus”, Vietnam Journal of Chemistry, 58:3 (2020), 410
D. A. Khochenkov, Yu. A. Khochenkova, Yu. S. Machkova, R. E. Gasanov, E. V. Stepanova, A. S. Bunev, “Synthesis and cytotoxic activity of novel 4-amino-5-cyano-2-sulfonylpyrimidines”, Mendeleev Commun., 30:5 (2020), 604–606
Yevhenii V. Hrynyshyn, Anna R. Musiychuk, Nazar M. Tsizorik, Andriy V. Bol'but, Mikhailo V. Vovk, “Synthesis of 4-aryl(hetaryl)pyrazolo[1,5-a]pyrazines by palladium-catalyzed Suzuki–Miyaura cross coupling”, Chem Heterocycl Comp, 55:11 (2019), 1070
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