D. V. Belyaev, D. L. Chizhov, M. I. Kodess, M. A. Ezhikova, G. L. Rusinov, V. N. Charushin, “Synthesis of 2-(polyfluoromethyl)pyrimido-[1,2-a]benzimidazole-4-carbaldehyde derivatives”, Mendeleev Commun., 29:3 (2019), 249

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Mendeleev Communications, 2019, Volume 29, Issue 3, Pages 249–251
DOI: https://doi.org/10.1016/j.mencom.2019.05.002 (Mi mendc1485)

This article is cited in 5 scientific papers (total in 5 papers)

Communications

Synthesis of 2-(polyfluoromethyl)pyrimido-[1,2-a]benzimidazole-4-carbaldehyde derivatives

D. V. Belyaev^a, D. L. Chizhov^a, M. I. Kodess^ab, M. A. Ezhikova^a, G. L. Rusinov^ab, V. N. Charushin^ab

^a I.Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, Ekaterinburg, Russian Federation
^b Institute of Chemical Engineering, Ural Federal University, Ekaterinburg, Russian Federation

Full-text PDF (299 kB) Citations (5)

DOI: https://doi.org/10.1016/j.mencom.2019.05.002

Graphic abstract: Synthesis of 2-(polyfluoromethyl)pyrimido-[1,2-<i>a</i>]benzimidazole-4-carbaldehyde derivatives

Abstract: A simple and efficient synthesis of 2-R^F-pyrimido[1,2-a]benzimidazole-4-carbaldehyde derivatives comprises the reaction between 3-(polyfluoroacetyl)pyruvaldehyde dimethyl acetals and 2-aminobenzimidazole. The effects of fluorinated substituents in 3-(polyfluoroacetyl)pyruvaldehyde dimethyl acetals and the reaction conditions on regiochemical outcome of this reaction have been estimated.

Document Type: Article

Language: English

*Supplementary materials:*
		Supplementary_data_1.pdf	(1.2 Mb)

Citation: D. V. Belyaev, D. L. Chizhov, M. I. Kodess, M. A. Ezhikova, G. L. Rusinov, V. N. Charushin, “Synthesis of 2-(polyfluoromethyl)pyrimido-[1,2-a]benzimidazole-4-carbaldehyde derivatives”, Mendeleev Commun., 29:3 (2019), 249–251

Linking options:

https://www.mathnet.ru/eng/mendc1485

https://www.mathnet.ru/eng/mendc/v29/i3/p249

This publication is cited in the following 5 articles:

Yu. O. Edilova, E. A. Osipova, Yu. S. Kudyakova, P. A. Slepukhin, V. I. Saloutin, D. N. Bazhin, “Polyfunctionalized pyrimidines based on 1,2,4-triketones”, Russ Chem Bull, 73:7 (2024), 1968
Satyanarayana Gadde, Ane Kleynhans, Jessica K. Holien, Mohan Bhadbhade, Phuoc Linh Dan Nguyen, Ritu Mittra, Tsz Tin Yu, Daniel R. Carter, Michael W. Parker, Glenn M. Marshall, Belamy B. Cheung, Naresh Kumar, “Pyrimido[1,2-a]benzimidazoles as inhibitors of oncoproteins ubiquitin specific protease 5 and MYCN in the childhood cancer neuroblastoma”, Bioorganic Chemistry, 136 (2023), 106462
D. N. Bazhin, Yu. S. Kudyakova, Yu. O. Edilova, Ya. V. Burgart, V. I. Saloutin, “Fluorinated 1,2,4-triketone analogs: new prospects for heterocyclic and coordination chemistry”, Russ Chem Bull, 71:7 (2022), 1321
Victor V. Fedotov, Vladimir L. Rusinov, Evgeny N. Ulomsky, Evgeny M. Mukhin, Evgeny B. Gorbunov, Oleg N. Chupakhin, “Pyrimido[1,2-a]benzimidazoles: synthesis and perspective of their pharmacological use”, Chem Heterocycl Comp, 57:4 (2021), 383
Vitaly A. Osyanin, Dmitry V. Osipov, Kirill S. Korzhenko, Oleg P. Demidov, Yuri N. Klimochkin, “4H-Chromenes as 1,3-bielectrophiles in the reaction with 2-aminobenzimidazole: synthesis of pyrimido[1,2-a]benzimidazoles”, Chem Heterocycl Comp, 57:5 (2021), 588

Citing articles in Google Scholar: Russian citations, English citations
Related articles in Google Scholar: Russian articles, English articles

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