V. V. Abzianidze, D. S. Prokofieva, P. P. Beltyukov, V. A. Kuznetsov, A. S. Bogachenkov, K. S. Rodygin, “Phosphorylated flavonoids as selective carboxylesterase inhibitors”, Mendeleev Commun., 29:1 (2019), 61

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Mendeleev Communications, 2019, Volume 29, Issue 1, Pages 61–63
DOI: https://doi.org/10.1016/j.mencom.2019.01.020 (Mi mendc1422)

This article is cited in 2 scientific papers (total in 2 papers)

Communications

Phosphorylated flavonoids as selective carboxylesterase inhibitors

V. V. Abzianidze^a, D. S. Prokofieva^b, P. P. Beltyukov^a, V. A. Kuznetsov^a, A. S. Bogachenkov^c, K. S. Rodygin^c

^a Research Institute of Hygiene, Occupational Pathology and Human Ecology, Leningrad region, Russian Federation
^b Institute of Experimental Pharmacology, Leningrad Region, Russian Federation
^c Institute of Chemistry, St. Petersburg State University, St. Petersburg, Russian Federation

Full-text PDF (241 kB) Citations (2)

DOI: https://doi.org/10.1016/j.mencom.2019.01.020

Graphic abstract: Phosphorylated flavonoids as selective carboxylesterase inhibitors

Abstract: A series of phosphorylated flavonoids has been synthesized and evaluated in vitro for inhibitory activity against carboxylesterase, acetylcholinesterase and butyrylcholinesterase as well as for their cytotoxicity towards human adenocarcinoma A549 and human glioblastoma U251 cell lines. Diethylphosphoryl derivatives of chrysin and 7-hydroxyflavone were found to be the most effective with bimolecular rate constants for carboxylesterase inhibition k_i=2.0×10⁶ and 5.7×10⁶dm³mol⁻¹min⁻¹, respectively.

Document Type: Article

Language: English

*Supplementary materials:*
		Supplementary_data_1.pdf	(1.5 Mb)

Citation: V. V. Abzianidze, D. S. Prokofieva, P. P. Beltyukov, V. A. Kuznetsov, A. S. Bogachenkov, K. S. Rodygin, “Phosphorylated flavonoids as selective carboxylesterase inhibitors”, Mendeleev Commun., 29:1 (2019), 61–63

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https://www.mathnet.ru/eng/mendc1422

https://www.mathnet.ru/eng/mendc/v29/i1/p61

This publication is cited in the following 2 articles:

P. A. Volkov, K. O. Khrapova, A. A. Telezhkin, A. I. Albanov, B. A. Trofimov, “Three-component reaction between phenanthridine, acetylenic ketones and bis(polyfluoroalkyl) H-phosphonates: synthesis of E-N-acylethenyl-6-bis(polyfluoroalkyl)phosphoryl-5,6-dihydrophenanthridines”, Russ Chem Bull, 73:1 (2024), 221
Yan Jia, Jiayue Wang, Peng Li, Xiaochi Ma, Keli Han, “Directionally Modified Fluorophores for Super-Resolution Imaging of Target Enzymes: A Case Study with Carboxylesterases”, J. Med. Chem., 64:21 (2021), 16177

Citing articles in Google Scholar: Russian citations, English citations
Related articles in Google Scholar: Russian articles, English articles

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