Novel 3-aroyl-5-arylidene-1,3-thiazolidine-2,4-diones: synthesis and antitumor activity

New 3-aroyl-5-arylidene-1,3-thiazolidine-2,4-diones were prepared by the Knoevenagel condensation of 1,3-thiazolidine-2,4-dione with aromatic aldehydes, conversion of the thus obtained 5-arylidene derivatives into the corresponding N-potassium salts, and their final N-acylation with acyl chlorides. The in vitro antitumor efficacy of the compounds was evaluated by the MTT method.