Abstract:
Two strategies for the synthesis of the new fluorescent markers based on 1,8-naphthalimide under classical conditions (in a flask) and in a microflow reactor are compared and contrasted. The microflow method provides higher purity of products, better productivity and production time. The resulting markers were used to obtain fluorescently labeled polylactide-based nanoparticles that can be used to study the distribution of polylactide nanoparticles as drug delivery vehicles within tissues and living organisms.
Citation:
M. S. Oshchepkov, A. S. Semyonkin, A. O. Menkov, P. A. Melnikov, M. P. Valikhov, I. N. Solovieva, S. V. Tkachenko, J. A. Malinowskaya, “Microflow synthesis of fluorescent markers based on 1,8-naphthalimide for polylactide nanoparticles and bioimaging”, Mendeleev Commun., 30:6 (2020), 747–749
Linking options:
https://www.mathnet.ru/eng/mendc1312
https://www.mathnet.ru/eng/mendc/v30/i6/p747
This publication is cited in the following 4 articles:
Konstantin A. Kochetkov, Maxim S. Oshchepkov, Pavel A. Pavlov, Michail M. Il'in, Inna N. Soloveva, Alexander S. Oshchepkov, “Green chemistry approach for stereoselective aldol condensation catalyzed by amino acids under microflow conditions”, Chemical Engineering Research and Design, 201 (2024), 169
Maxim Oshchepkov, Sergey Tkachenko, Konstantin Popov, Aleksey Semyonkin, Danil Yuriev, Inna Solovieva, Pavel Melnikov, Julia A. Malinovskaya, Alexander Oshchepkov, “Continuous-flow synthesis of the naphthalimide derivatives for medical and engineering applications”, Dyes and Pigments, 231 (2024), 112386
A.A. Lubin, R.V. Yakushin, M.S. Oshchepkov, Yu.V. Ulyanova, D.O. Botev, A.V. Chistolinov, N.Ya. Podhaluzina, I.N. Solovieva, V.S. Boldyrev, “Acenaphthene Nitro Derivatives Plasma-Chemical Synthesis in the High-Frequency Currents Field at Reduced Pressure”, HoBMSTU.SNS, 2023, no. 4 (109), 123
M. A. Merkulova, N. S. Osipova, O. O. Maksimenko, M. G. Gordienko, S. E. Gelperina, “Easy size control of polymer nanoparticles obtained by emulsification–evaporation technique in a microfluidic reactor”, Mendeleev Commun., 31:6 (2021), 899–901
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