Abstract:
New N-aryl-2-{3-[ω-(4-bromophenoxy)alkyl]-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl}acetamides have been obtained from 1-[ω-(4-bromophenoxy)alkyl]uracil and 2-chloro-N-(4-phenoxyphenyl)acetamide derivatives. Investigation of their antiviral properties against human cytomegalovirus revealed that the representative with dodecane-1,12-diyl linker exhibited powerful virus inhibitory activity in vitro.
Citation:
M. P. Paramonova, R. Snoeck, G. Andrei, A. L. Khandazhinskaya, M. S. Novikov, “New acetamide derivatives containing (ω-p-bromophenoxyalkyl)uracil moiety and their anticytomegalovirus activity”, Mendeleev Commun., 30:5 (2020), 602–603
Linking options:
https://www.mathnet.ru/eng/mendc1265
https://www.mathnet.ru/eng/mendc/v30/i5/p602
This publication is cited in the following 9 articles:
Kashish Jain, Shivali Sharma, Divya Utreja, “Uracil: A Pharmacophore with Diverse Biological Potential”, ChemistrySelect, 9:5 (2024)
M. P. Paramonova, E. S. Gureeva, A. A. Ozerov, R. Snoeck, G. Andrei, D. A. Aleksandrov, A. L. Khandazhinskaya, M. S. Novikov, S. N. Kochetkov, “SYNTHESIS OF 1-[ω-(BROMOPHENOXY)ALKYL]-3-NAPHTHALENYLMETHYL DERIVATIVES OF URACIL AND THEIR ANALOGUES AS PROBABLE INHIBITORS OF HUMAN CYTOMEGALOVIRUS REPLICATION”, Doklady Rossijskoj akademii nauk. Nauki o žizni, 509:1 (2023), 170
Zeinab Hussain, Magdy A. Ibrahim, Nasser M. El-Gohary, Yassin A. Gabr, Hassan A. Allimony, Al-Shimaa Badran, “Utility of 6-Aminouracils for Building Substituted and Heteroannulated Pyrimidines: A Comprehensive Review”, HETEROCYCLES, 106:4 (2023), 594
M. P. Paramonova, E. S. Gureeva, A. A. Ozerova, R. Snoeck, G. Andrei, D. A. Alexandrov, A. L. Khandazhinskaya, M. S. Novikova, S. N. Kochetkov, “SYNTHESIS OF 1-[ω-(BROMOPHENOXY)ALKYL]-3-NAPHTHALENYLMETHYL DERIVATIVES OF URACIL AND THEIR ANALOGUES AS PROBABLE INHIBITORS OF HUMAN CYTOMEGALOVIRUS REPLICATION”, Doklady Rossijskoj akademii nauk. Nauki o žizni, 508:1 (2023), 35
M. P. Paramonova, E. S. Gureeva, A. A. Ozerov, R. Snoeck, G. Andrei, D. A. Aleksandrov, A. L. Khandazhinskaya, M. S. Novikov, S. N. Kochetkov, “Synthesis of 1-[ω-(Bromophenoxy)alkyl]-3-naphthalenylmethyl Derivatives of Uracil and Their Analogues As Probable Inhibitors of Human Cytomegalovirus Replication”, Dokl Biochem Biophys, 509:1 (2023), 41
M. S. Novikov, M. P. Paramonova, I. M. Kirillov, O. A. Smirnova, A. L. Khandazhinskaya, A. O. Chizhov, S. N. Kochetkov, A. V. Ivanov, I. F. Fedyakina, “New N1-(4-aryloxybenzyl)uracils containing N3-positioned 4-(trimethyleneoxy)benzoic acid moiety, and study of their antiviral activity against SARS-CoV-2 and influenza virus”, Mendeleev Commun., 33:4 (2023), 537–538
Andrei E. Siniavin, Mikhail S. Novikov, Vladimir A. Gushchin, Alexander A. Terechov, Igor A. Ivanov, Maria P. Paramonova, Elena S. Gureeva, Leonid I. Russu, Nadezhda A. Kuznetsova, Elena V. Shidlovskaya, Sergei I. Luyksaar, Daria V. Vasina, Sergei A. Zolotov, Nailya A. Zigangirova, Denis Y. Logunov, Alexander L. Gintsburg, “Antiviral Activity of N1,N3-Disubstituted Uracil Derivatives against SARS-CoV-2 Variants of Concern”, IJMS, 23:17 (2022), 10171
M. P. Paramonova, E. S. Gureeva, A. A. Ozerov, R. Snoeck, G. Andrei, D. A. Alexandrov, A. L. Handazinskaya, M. S. Novikov, S. N. Kochetkov, “Synthesis of 1-[ω-(Bromophenoxy)alkyl]-3-Naphthalenylmethyl Uracil Derivatives and Their Analogues as Probable Inhibitors of Human Cytomegalovirus Replication”, Dokl Biochem Biophys, 507:1 (2022), 357
O. I. Yarovaya, K. S. Kovaleva, S. S. Borisevich, T. V. Rybalova, Yu. V. Gatilov, E. O. Sinegubova, A. S. Volobueva, V. V. Zarubaev, N. F. Salakhutdinov, “Synthesis and antiviral properties of tricyclic amides derived from α-humulene and β-caryophyllene”, Mendeleev Commun., 32:5 (2022), 609–611
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