E. V. Nosova, O. A. Batanova, G. N. Lipunova, V. N. Charushin, “Synthesis of novel 8-nitro-substituted 1,3-benzothiazin-4-ones”, Mendeleev Commun., 30:4 (2020), 427

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Mendeleev Communications, 2020, Volume 30, Issue 4, Pages 427–429
DOI: https://doi.org/10.1016/j.mencom.2020.07.007 (Mi mendc1212)

This article is cited in 1 scientific paper (total in 1 paper)

Communications

Synthesis of novel 8-nitro-substituted 1,3-benzothiazin-4-ones

E. V. Nosova^ab, O. A. Batanova^b, G. N. Lipunova^ab, V. N. Charushin^ab

^a I.Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, Ekaterinburg, Russian Federation
^b Institute of Chemical Engineering, Ural Federal University, Ekaterinburg, Russian Federation

Full-text PDF (210 kB) Citations (1)

DOI: https://doi.org/10.1016/j.mencom.2020.07.007

Graphic abstract: Synthesis of novel 8-nitro-substituted 1,3-benzothiazin-4-ones

Abstract: New 2,5-bis(azacyclohex-1-yl)-8-nitro-1,3-benzothiazin-4-ones were synthesized from 2,6-difluorobenzoic acid in two preparative stages. The ethoxycarbonylpiperazino derivative surpasses in tuberculostatic activity (MIC 4μgml⁻¹) its 5-fluoro-8-H-counterpart. The first representative of 5-fluoro-8-nitro-1,3-benzothiazin-4-ones was obtained through the condensation of 2,6-difluoro-3-nitrobenzoyl isothiocyanate and N-methylindole.

Keywords: 1,3-benzothiazin-4-ones, nitro compounds, benzoyl isothiocyanates, heterocyclization, amino defluorination, organofluorine compounds, tuberculostatic activity.

Document Type: Article

Language: English

*Supplementary materials:*
		Supplementary_data_1.pdf	(1.3 Mb)

Citation: E. V. Nosova, O. A. Batanova, G. N. Lipunova, V. N. Charushin, “Synthesis of novel 8-nitro-substituted 1,3-benzothiazin-4-ones”, Mendeleev Commun., 30:4 (2020), 427–429

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https://www.mathnet.ru/eng/mendc/v30/i4/p427

This publication is cited in the following 1 articles:

Citing articles in Google Scholar: Russian citations, English citations
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