Abstract:
New cis-bis[N-(2-nitroxyethyl)isonicotinamide-N]platinum(iv) tetrachloride hybrid materials were obtained via its solubilization by nanoparticles of N-vinylpyrrolidone copolymer with dimethacrylates and characterized. The materials containing 2% of PtIV complex cause a cytotoxic effect on the tumor A-172 cells; IC50 values were ca. 106μm after incubation for 48h.
Citation:
S. V. Kurmaz, N. V. Fadeeva, B. S. Fedorov, G. I. Kozub, N. S. Emelyanova, V. A. Kurmaz, R. A. Manzhos, A. A. Balakina, A. A. Terentyev, “New antitumor hybrid materials based on PtIV organic complex and polymer nanoparticles consisting of N-vinylpyrrolidone and (di)methacrylates”, Mendeleev Commun., 30:1 (2020), 22–24
Linking options:
https://www.mathnet.ru/eng/mendc1088
https://www.mathnet.ru/eng/mendc/v30/i1/p22
This publication is cited in the following 20 articles:
Svetlana V. Kurmaz, Roman I. Komendant, Evgenia O. Perepelitsina, Vladimir A. Kurmaz, Igor I. Khodos, Nina S. Emelyanova, Natalia V. Filatova, Vera I. Amozova, Anastasia A. Balakina, Alexey A. Terentyev, “New Amphiphilic Terpolymers of N-Vinylpyrrolidone with Acrylic Acid and Triethylene Glycol Dimethacrylate as Promising Drug Delivery: Design, Synthesis and Biological Properties In Vitro”, IJMS, 25:15 (2024), 8422
V. A. Kurmaz, D. V. Konev, S. V. Kurmaz, N. S. Emelyanova, “Electrochemical study of the free form of anti-tumor antibiotic doxorubicin and encapsulated in a biocompatible copolymer of N-vinyl pyrrolidone with (di)methacrylates”, Èlektrohimiâ, 60:4 (2024), 309
V. A. Kurmaz, D. V. Konev, S. V. Kurmaz, N. S. Emel'yanova, “Electrochemical Study of the Antitumor Antibiotic Doxorubicin in Its Free Form and Encapsulated in a Biocompatible Copolymer of N-Vinylpyrrolidone and (di)Methacrylates”, Russ J Electrochem, 60:4 (2024), 321
Alexander Yu. Rybkin, Svetlana V. Kurmaz, Elizaveta A. Urakova, Natalia V. Filatova, Lev R. Sizov, Alexey V. Kozlov, Mikhail O. Koifman, Nikolai S. Goryachev, “Nanoparticles of N-Vinylpyrrolidone Amphiphilic Copolymers and Pheophorbide a as Promising Photosensitizers for Photodynamic Therapy: Design, Properties and In Vitro Phototoxic Activity”, Pharmaceutics, 15:1 (2023), 273
Svetlana V. Kurmaz, Evgenia O. Perepelitsina, Sergey G. Vasiliev, Irina A. Avilova, Igor I. Khodos, Vladimir A. Kurmaz, Dmitry A. Chernyaev, Yuliya V. Soldatova, Natalia V. Filatova, Irina I. Faingold, “Macromolecular Design and Engineering of New Amphiphilic N-Vinylpyrrolidone Terpolymers for Biomedical Applications”, IJMS, 24:20 (2023), 15170
S. V. Kurmaz, I. I. Ivanova, N. V. Fadeeva, V. M. Ignatiev, N. S. Emelyanova, M. A. Lapshina, A. A. Balakina, A. A. Terentiev, “Nanoscale systems folic acid—amphiphilic copolymer of N-vinylpyrrolidone with methacrylic acid, branched with triethylene glycol dimethacrylate”, Russ Chem Bull, 72:6 (2023), 1349
Yuliya V. Soldatova, Irina I. Faingold, Darya A. Poletaeva, Alexei V. Kozlov, Nina S. Emel'yanova, Igor I. Khodos, Dmitry A. Chernyaev, Svetlana V. Kurmaz, “Design and Investigation of New Water-Soluble Forms of α-Tocopherol with Antioxidant and Antiglycation Activity Using Amphiphilic Copolymers of N-Vinylpyrrolidone”, Pharmaceutics, 15:5 (2023), 1388
S. V. Kurmaz, I. I. Ivanova, N. S. Emelyanova, D. V. Konev, V. A. Kurmaz, N. V. Filatova, A. A. Balakina, A. A. Terentyev, “Doxorubicin compositions with biocompatible terpolymer of N-vinylpyrrolidone, methacrylic acid and triethylene glycol dimethacrylate”, Mendeleev Commun., 33:2 (2023), 255–258
Svetlana V. Kurmaz, Natalia V. Fadeeva, Adelina V. Komendant, Vladislav M. Ignatiev, Nina S. Emelyanova, Gennady V. Shilov, Tatyana S. Stupina, Natalia V. Filatova, Maria A. Lapshina, Alexei A. Terentyev, “New amphiphilic terpolymers of N-vinylpyrrolidone with poly(ethylene glycol) methyl ether methacrylate and triethylene glycol dimethacrylate as carriers of the hydrophobic fluorescent dye”, Polym. Bull., 79:10 (2022), 8905
Svetlana V. Kurmaz, Vladislav M. Ignatiev, Nina S. Emel'yanova, Vladimir A. Kurmaz, Dmitry V. Konev, Anastasiya A. Balakina, Alexey A. Terentyev, “New Nanosized Systems Doxorubicin—Amphiphilic Copolymers of N-Vinylpyrrolidone and (Di)methacrylates with Antitumor Activity”, Pharmaceutics, 14:12 (2022), 2572
Marina Gorbunova, Larisa Lemkina, Yulia Beloglazova, “Phosphorous-containing copolymers loaded with silver nanoparticles for biomedical purposes”, Chim.Tech.Acta, 9:2S (2022)
S. V. Kurmaz, I. I. Ivanova, N. V. Fadeeva, E. O. Perepelitsina, M. A. Lapshina, A. A. Balakina, A. A. Terent'ev, “New Amphiphilic Branched Copolymers of N-Vinylpyrrolidone with Methacrylic Acid for Biomedical Applications”, Polym. Sci. Ser. A, 64:5 (2022), 434
S. V. Kurmaz, N. V. Fadeeva, J. A. Skripets, R. I. Komendant, V. M. Ignatiev, N. S. Emelyanova, J. V. Soldatova, I. I. Faingold, D. A. Poletaeva, R. A. Kotelnikova, “New water-soluble forms of α-tocopherol: preparation and study of antioxidant activity in vitro”, Mendeleev Commun., 32:1 (2022), 117–119
V. M. Ignat'ev, N. S. Emel'yanova, S. V. Kurmaz, N. V. Fadeeva, “Hydrogen bonds formed upon encapsulation of doxorubicin into amphiphilic N-vinylpyrrolidone copolymer: a quantum chemical study”, Russ Chem Bull, 70:7 (2021), 1269
Svetlana V. Kurmaz, Natalia V. Fadeeva, Anna I. Gorshkova, Sergey A. Kurochkin, Eugenia I. Knerelman, Galina I. Davydova, Vladimir I. Torbov, Nadezhda N. Dremova, Dmitry V. Konev, Vladimir A. Kurmaz, Vladislav M. Ignatiev, Nina S. Emelyanova, “Mesoporous Networks of N-Vinylpyrrolidone with (di)Methacrylates as Precursors of Ecological Molecular Imprinted Polymers”, Materials, 14:22 (2021), 6757
M. N. Gorbunova, T. D. Batueva, D. M. Kiselkov, V. N. Strelnikov, “Silver nanocomposites based on copolymers of N,N-diallyl-N'-acetylhydrazine with N-vinylpyrrolidone”, Russ Chem Bull, 70:9 (2021), 1706
S. V. Kurmaz, N. V. Fadeeva, B. S. Fedorov, G. I. Kozub, V. A. Kurmaz, V. M. Ignat'ev, N. S. Emel'yanova, “Amphiphilic copolymers of N-vinylpyrrolidone with (di)methacrylates as promising carriers for the platinum(IV) complex with antitumor activity”, Russ Chem Bull, 70:9 (2021), 1832
S. V. Kurmaz, N. V. Fadeeva, A. A. Grishchuk, N. S. Emel'yanova, V. M. Ignat'ev, G. V. Shilov, Yu. V. Soldatova, I. I. Faingold, R. A. Kotel'nikova, “Hybrid Materials Based on Dimethylbiguanide (Metformin) and Copolymer of N-Vinylpyrrolidone with Triethylene Glycol Dimethacrylate”, Polym. Sci. Ser. A, 63:2 (2021), 106
Svetlana V. Kurmaz, Natalia V. Fadeeva, Vladislav M. Ignat'ev, Vladimir A. Kurmaz, Sergei A. Kurochkin, Nina S. Emel'yanova, “Structure and State of Water in Branched N-Vinylpyrrolidone Copolymers as Carriers of a Hydrophilic Biologically Active Compound”, Molecules, 25:24 (2020), 6015
S V Kurmaz, D V Konev, V D Sen', V A Kurmaz, A V Kulikov, “Preparation and characterization of stable water soluble hybrid nanostructures of hydrophobic compounds by encapsulation into nanoparticles of amphiphilic N-vinylpyrrolidone copolymers of new generation”, IOP Conf. Ser.: Mater. Sci. Eng., 848:1 (2020), 012043
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