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Matematicheskaya Biologiya i Bioinformatika, 2021, Volume 16, Issue 2, Pages 256–298
DOI: https://doi.org/10.17537/2021.16.256
(Mi mbb467)
 

This article is cited in 3 scientific papers (total in 3 papers)

Review Articles

Variety of non-coding RNAs in eukaryotic genomes

N. N. Nazipova

Institute of Mathematical Problems of Biology RAS, Pushchino, Moskovskaya obl.
References:
Abstract: The genomes of large multicellular eukaryotes mainly consist of DNA that encodes not proteins, but RNAs. The unexpected discovery of approximately the same number of protein genes in Homo sapiens and Caenorhabditis elegans led to the understanding that it is not the number of proteins that determines the complexity of the development and functioning of an organism. The phenomenon of pervasive transcription of genomes is finding more and more confirmation. Data are emerging on new types of RNA that work in different cell compartments, are expressed at different stages of development, in different tissues and perform various functions. Their main purpose is fine regulation of the main cellular processes. The presence of a rich arsenal of regulators that can interact with each other and work on the principle of interchangeability determines the physiological complexity of the organism and its ability to adapt to changing environmental conditions. An overview of the currently known functional RNAs expressed in eukaryotic genomes is presented here. There is no doubt that in the near future, using high-tech transcriptome technologies, many new RNAs will be identified and characterized. But it is likely that many of the expressed transcripts do not have a function, but are an evolutionary reserve of organisms.
Key words: RNA-interference, pervasive transcription, miRNA, siRNA, snRNA, snoRNA, piRNA, long noncoding RNA, circular RNA, tRNA derived fragments, rRNA-derived fragments, transposon-derived noncoding RNA.
Funding agency Grant number
Russian Foundation for Basic Research 19-07-00996
Received 03.06.2021, 13.08.2021, Published 26.08.2021
Bibliographic databases:
Document Type: Article
Language: Russian
Citation: N. N. Nazipova, “Variety of non-coding RNAs in eukaryotic genomes”, Mat. Biolog. Bioinform., 16:2 (2021), 256–298
Citation in format AMSBIB
\Bibitem{Naz21}
\by N.~N.~Nazipova
\paper Variety of non-coding RNAs in eukaryotic genomes
\jour Mat. Biolog. Bioinform.
\yr 2021
\vol 16
\issue 2
\pages 256--298
\mathnet{http://mi.mathnet.ru/mbb467}
\crossref{https://doi.org/10.17537/2021.16.256}
\elib{https://elibrary.ru/item.asp?id=47918034}
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  • https://www.mathnet.ru/eng/mbb/v16/i2/p256
  • This publication is cited in the following 3 articles:
    Citing articles in Google Scholar: Russian citations, English citations
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