Abstract:
In the current report, the effect of bioactive compounds of the M2 macrophage secretome on transcription of hippocampal genes in mice with a depression-like condition caused by social stress has been investigated. Surgically resected hippocampus was used for mRNA isolation with following RNA sequencing procedures. Comparative analysis of transcriptomes from the control depressive mice treated with physiological saline solution and mice after intranasal administration of M2 macrophages-conditioned medium revealed that remission of the depressive-like state is associated with a significant up- and downregulation of a number of genes, which were found to participate in restoration/regulation of ATP/Adenosine balance. Among the events associated with positive changes in behavioral pattern of depressive mice, the switch of microglial environment from a pro-inflammatory phenotype to an anti-inflammatory one, and subsequent restoration of compromised cannabinoid and glutamatergic transmitter pathways has been predicted.
Received 29.09.2020, 24.11.2020, Published 08.12.2020
Document Type:
Article
Language: Russian
Citation:
E. Ya. Shevela, E. V. Markova, M. A. Knyazheva, A. S. Proskurina, Ya. R. Efremov, V. V. Molodtsov, I. A. Seledtsov, A. A. Ostanin, S. S. Bogachev, N. A. Kolchanov, E. R. Chernykh, “Changes in the hippocampal genes transcriptome in depression model mice upon intranasal exposure to M2 macrophage secretome factors”, Mat. Biolog. Bioinform., 15:2 (2020), 357–393
\Bibitem{SheMarKny20}
\by E.~Ya.~Shevela, E.~V.~Markova, M.~A.~Knyazheva, A.~S.~Proskurina, Ya.~R.~Efremov, V.~V.~Molodtsov, I.~A.~Seledtsov, A.~A.~Ostanin, S.~S.~Bogachev, N.~A.~Kolchanov, E.~R.~Chernykh
\paper Changes in the hippocampal genes transcriptome in depression model mice upon intranasal exposure to M2 macrophage secretome factors
\jour Mat. Biolog. Bioinform.
\yr 2020
\vol 15
\issue 2
\pages 357--393
\mathnet{http://mi.mathnet.ru/mbb436}
\crossref{https://doi.org/10.17537/2020.15.357}
Linking options:
https://www.mathnet.ru/eng/mbb436
https://www.mathnet.ru/eng/mbb/v15/i2/p357
This publication is cited in the following 1 articles:
R. F. Enikeeva, A. V. Kazantseva, Yu. D. Davydova, R. N. Mustafin, Z. R. Takhirova, S. B. Malykh, Y. V. Kovas, E. K. Khusnutdinova, “The role of inflammatory system genes in individual differences in nonverbal intelligence”, Vestn. VOGiS, 26:2 (2022), 179
Citation in format AMSBIB
Contact us: