|
This article is cited in 3 scientific papers (total in 3 papers)
Mathematical Modeling
A mathematical model linking Ca$^{2+}$-dependent signaling pathway and gene expression regulation in
human skeletal muscle
I. R. Akberdinabc, A. Yu. Vertyshevd, S. S. Pintusae, D. V. Popovf, F. A. Kolpakovae a BIOSOFT.RU, LLC, Novosibirsk, Russian Federation
b Federal Research Center Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia
c Novosibirsk State University, Novosibirsk, Russian Federation
d CJSC "Sites-Tsentr", Moscow, Russian Federation
e Institute of Computational Technologies, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation
f Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Russia
Abstract:
. The physiological adaptation to aerobic endurance exercises is provided by activation of signaling pathways in skeletal muscle cells. Training-induced activation of specific signaling pathways results in significant transcriptional responses. Despite the ongoing endeavours to experimentally investigate regulatory mechanisms and signal transduction pathways involved in the contraction-induced adaptation, quantitative contribution of certain signal molecules in expression regulation of genes responsible for intracellular response has not been studied comprehensively yet. The paper presents novel developed model linking Ca$^{2+}$-dependent signaling pathway and downstream transcription regulation of early and late response genes in human skeletal muscle during exercise. Numerical analysis of the model enabled to reveal crucial steps in this signal transduction pathway for the adaptation and demonstrated the necessity of consideration of additional transcription factors regulating transcription of late response genes in order to adequately reproduce gene expression data that were taken in human vastus lateralis muscle during and after acute cycling exercise.
Key words:
mathematical model, skeletal muscle, physical exercise, Ca$^{2+}$-dependent signaling pathway, transcriptome, RNA sequencing, regulation of expression, BioUML.
Received 01.10.2019, 10.01.2020, Published 05.02.2020
Citation:
I. R. Akberdin, A. Yu. Vertyshev, S. S. Pintus, D. V. Popov, F. A. Kolpakov, “A mathematical model linking Ca$^{2+}$-dependent signaling pathway and gene expression regulation in
human skeletal muscle”, Mat. Biolog. Bioinform., 15:1 (2020), 20–39
Linking options:
https://www.mathnet.ru/eng/mbb420 https://www.mathnet.ru/eng/mbb/v15/i1/p20
|
|