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Matematicheskaya Biologiya i Bioinformatika, 2019, Volume 14, Issue 2, Pages 373–392
DOI: https://doi.org/10.17537/2019.14.373
(Mi mbb390)
 

This article is cited in 5 scientific papers (total in 5 papers)

Mathematical Modeling

A modular visual model of energy metabolism in human skeletal muscle

I. N. Kiselevab, I. R. Akberdinbcd, A. Vertysheve, D. V. Popovf, F. A. Kolpakovab

a Institute of Computational Technologies, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation
b BIOSOFT.RU, LLC, Novosibirsk, Russian Federation
c Novosibirsk State University, Novosibirsk, Russian Federation
d Federal Research Center Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia
e CJSC "Sites-Tsentr", Moscow, Russian Federation
f Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Russia
References:
Abstract: The paper presents a modification of a multi-compartmental mathematical model describing the dynamics of intracellular species concentrations and fluxes in human muscle at rest. A modular representation of a complex model is proposed, which provides the possibility of rapid expansion and modification of the model compartments to account for the complex organization of muscle cells and the limitations of the rate of diffusion of metabolites between intracellular compartments. To illustrate the work of the model, intracellular response in human skeletal muscle to acute aerobic two-legged cycle ergometer training was considered. The model in SBML format is available at http://wiki.biouml.org/index.php/Muscle-metabolism.
Key words: mathematical model, module modeling approach, skeletal muscle, physical exercise, metabolism, physiology, BioUML.
Funding agency Grant number
Russian Foundation for Basic Research 17-00-00308
17-00-00296
Received 23.05.2019, 27.06.2019, Published 11.07.2019
Document Type: Article
UDC: 573.22, 57.032-033
Language: Russian
Citation: I. N. Kiselev, I. R. Akberdin, A. Vertyshev, D. V. Popov, F. A. Kolpakov, “A modular visual model of energy metabolism in human skeletal muscle”, Mat. Biolog. Bioinform., 14:2 (2019), 373–392
Citation in format AMSBIB
\Bibitem{KisAkbVer19}
\by I.~N.~Kiselev, I.~R.~Akberdin, A.~Vertyshev, D.~V.~Popov, F.~A.~Kolpakov
\paper A modular visual model of energy metabolism in human skeletal muscle
\jour Mat. Biolog. Bioinform.
\yr 2019
\vol 14
\issue 2
\pages 373--392
\mathnet{http://mi.mathnet.ru/mbb390}
\crossref{https://doi.org/10.17537/2019.14.373}
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  • https://www.mathnet.ru/eng/mbb/v14/i2/p373
  • This publication is cited in the following 5 articles:
    Citing articles in Google Scholar: Russian citations, English citations
    Related articles in Google Scholar: Russian articles, English articles
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    Full-text PDF :79
    References:17
     
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