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Matematicheskaya Biologiya i Bioinformatika, 2018, Volume 13, Issue 2, Pages 563–590
DOI: https://doi.org/10.17537/2018.13.563
(Mi mbb356)
 

This article is cited in 3 scientific papers (total in 3 papers)

Information and Computer Technologies in Biology and Medicine

Optimal partitioning method for evaluating of effect of hemoglobin oxygenation levels of vessel endothelial growth factor

O. V. Senkoa, M. S. Kodryanb, A. V. Kuznetsovac, L. L. Klimenkod, A. I. Deevd, I. S. Baskakovd, A. N. Mazilinae

a FRC «Computer Science and Control» of RAS
b Lomonosov Moscow State University
c Emanuel Institute of Biochemical Physics of RAS
d Semenov Institute of Chemical Physics of RAS
e Department of Neurology, Clinical Hospital ¹123, FMBA of Russia
Full-text PDF (589 kB) Citations (3)
References:
Abstract: The work is aimed to study relationship between vessel endothelial growth factor (VEGF) serum levels and hypoxia in patients with severe neurological disorders. Overviewed literature sources indicate activation of VEGF synthesis during hypoxia. But standard correlation analysis does not reveal a statistically significant association between VEGF levels and pulse oxymetry parameters objectively assessing oxygen supply. Due to a proposed in the paper technique it became possible to reveal valid relationship between VEGF levels and oxygenation. This relationship can be described as increase of correlation between VEGF and immunological complement C4 when oxygenation level is below a certain threshold. Developed method includes searching of such boundaries for oxymetry parameters that correlation coefficients between VEGF and some additional factor Z in formed group are maximally different. ranges. The original technique based on permutation test was used not only to asses validity of effects associated with each oxymetry parameter but also to evaluate joint effect by full group of such factors. Great number of variable from database were tested as additional factors/ So additional correction of validity was made to take into account multiple testing.
Key words: vessel endothelial growth factor, hypoxia, verification, permutation test, multiple testing.
Funding agency Grant number
Russian Foundation for Basic Research 18-01-00557_à
17-07-01362_à
Received 28.08.2018, Published 27.12.2018
Document Type: Article
UDC: 004.852
Language: Russian
Citation: O. V. Senko, M. S. Kodryan, A. V. Kuznetsova, L. L. Klimenko, A. I. Deev, I. S. Baskakov, A. N. Mazilina, “Optimal partitioning method for evaluating of effect of hemoglobin oxygenation levels of vessel endothelial growth factor”, Mat. Biolog. Bioinform., 13:2 (2018), 563–590
Citation in format AMSBIB
\Bibitem{SenKodKuz18}
\by O.~V.~Senko, M.~S.~Kodryan, A.~V.~Kuznetsova, L.~L.~Klimenko, A.~I.~Deev, I.~S.~Baskakov, A.~N.~Mazilina
\paper Optimal partitioning method for evaluating of effect of hemoglobin oxygenation levels of vessel endothelial growth factor
\jour Mat. Biolog. Bioinform.
\yr 2018
\vol 13
\issue 2
\pages 563--590
\mathnet{http://mi.mathnet.ru/mbb356}
\crossref{https://doi.org/10.17537/2018.13.563}
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  • https://www.mathnet.ru/eng/mbb356
  • https://www.mathnet.ru/eng/mbb/v13/i2/p563
  • This publication is cited in the following 3 articles:
    Citing articles in Google Scholar: Russian citations, English citations
    Related articles in Google Scholar: Russian articles, English articles
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    Abstract page:250
    Full-text PDF :184
    References:32
     
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